1191269-06-3Relevant articles and documents
Chemoenzymatic process for the preparation of (S)-7-((tert-butyldiphenylsilyl)oxy)hept-1-yn-4-ol in a continuous packed-bed reactor, a key intermediate for eribulin synthesis
Basetty, Shalini,Chandrasekhar, Srivari,Ghosh, Subhash,Krishna, Avula Shiva,Kumaraguru, Thenkrishnan,Mainkar, Prathama S.,Nasam, Rajesh,Pabbaraja, Srihari,Ralte, Samuel L.,Reddy, Chada Raji,Sudhakar, Gangarajula
, p. 2657 - 2664 (2020)
A practical chemoenzymatic process has been developed for the preparation of optically pure (S)-7-((tertbutyldiphenylsilyl) oxy)hept-1-yn-4-ol, (S)-4. This was prepared via enantioselective acylation of racemic homopropargylic alcohol (+/-)-4 catalyzed by
Catalytic enantioselective Cr-Mediated propargylation: application to halichondrin synthesis
Liu, Songbai,Kim, Joseph T.,Dong, Cheng-Guo,Kishi, Yoshito
supporting information; experimental part, p. 4520 - 4523 (2009/12/08)
A catalytic enantioselective propargylation In the presence of 10 mol % of Cr catalyst prepared from Cr(III) bromide and (R)-sulfonamide E furnishes homopropargyl alcohol 8 In 78% yield with 90% ee. Coupled with the workup based on Amano-llpase, this meth