1192-08-1

Usage

Uses

Used in Organic Synthesis:
3-Methylcyclobutan-1-one is used as a building block in organic synthesis for its ability to serve as a starting material for the preparation of various other organic compounds, showcasing its utility in creating a wide range of chemical products.
Used in the Fragrance Industry:
3-Methylcyclobutan-1-one is used as a scent ingredient in perfumes and other personal care products, capitalizing on its distinct odor to enhance the fragrance profiles of these consumer goods.
Used in Pharmaceutical Development:
3-Methylcyclobutan-1-one is utilized in pharmaceuticals due to its potential applications in the development of new drugs, leveraging its reactivity in organic reactions to create novel medicinal compounds.
Used in Agrochemicals:
3-Methylcyclobutan-1-one is employed in agrochemicals for its potential to contribute to the development of new pesticides or other agricultural chemicals, again due to its versatile reactivity in organic reactions.
Used as a Solvent in Chemical Processes:
3-Methylcyclobutan-1-one is used as a solvent in various chemical processes, where its properties allow for the efficient dissolution and interaction of other compounds in different chemical reactions.

Upstream product

• 99182-70-4 3-methylene-cyclobutanon-diethylacetal 
• 822-76-4 3-Methyl-bicyclo<1.1.0>butancarbonsaeureamid 
• 15189-18-1 1-methyl-3-methylenecyclobutane 
• 75-89-8 2,2,2-trifluoroethanol 
• 70106-30-8 3-methyl-1-cyclobutenyl nonaflate 
• 90150-80-4 3-methyl-cyclobutanecarbonyl chloride 
• 2117-11-5 4-pentyn-2-ol 
• 1254062-42-4 3-methyl-1-(methylsulfinyl)-1-(methylthio)cyclobutane 
• 53177-35-8 1-Chloro-2,3-dimethyl-cyclopropane 
• 32264-68-9 1,1-Dibromo-2,3-dimethylcyclopropane 
• 18631-84-0 1-methyl-2-methylenecyclopropane 
• 52194-08-8 trans-1,2-Dimethyl-3-bromcyclopropan 
• 90370-75-5 Essigsaeure-(3-methyl-cyclobutylmethylester) 
• 90226-19-0 Dimethyl-<3-methyl-cyclobutylmethyl>-amin 

Downstream Products

• 89180-79-0 2-Brom-1-methyl-cyclobutanon-(3) 
• 6142-57-0 (+/-)-trans-2-methylcyclopropanecarboxylic acid 
• 1192-25-2 (+/-)-trans-2-Brom-3-methyl-cyclobutanon 
• 65284-00-6 (R)-3-methyl-γ-butyrolactone 
• 64190-48-3 (S)-3-methyl-4-butanolide 
• 1381847-62-6 C₂₉H₃₉F₂N₃O₃ 
• 939453-57-3 C₂₉H₄₀FN₃O₃ 

Relevant academic research and scientific papers

Round-Trip Radical Probes: Ring Cleavage of the Bicyclopentylcarbinyl Radical

The novel concept of a round-trip probe for radical intermediates in reaction mechanisms is proposed and defined in this paper.A round-trip radical probe undergoes skeletal rearrangements such that the radical is returned to its site of origin.These probes should be especially useful for the study of enzyme mechanisms, since the special requirements of the active site may lead to ambiguous results using standard nonround-trip radical probes.The ring cleavages and rearrangements of the bicyclopentylcarbinyl radical are described as the prototypical round-trip radical probe.We have measured the rate constant for the ring opening of the bicyclopentylcarbinyl radical over the temperature range -42 to 60 deg C and have determined a temperature-dependent function for the ring opening of log (k3/s-1) = 12.78 (+/-0.26) - 7.79 (+/-0.35)/θ and a rate constant for ring opening of 1.15 * 107 s-1 at 25 deg C.

HPK1 INHIBITORS, PREPARATION METHOD AND APPLICATION THEREOF

Disclosed are HPK-1 inhibitors having a structure represented by Formula (X), pharmaceutical compositions comprising the HPK-1 inhibitors, methods of using the HPK-1 inhibitors, such as treating cancers, methods of preparing the HPK-1 inhibitors, and the synthetic intermediates.

Structure guided P1′ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer's disease

The synthesis and SAR of a series of BACE-1 hydroxyethyl amine inhibitors containing substitutions on a spirocyclobutyl moiety is described. Selectivity against cathepsin D, a related aspartyl protease with potential off target toxicity, and improved micr

BETA-SECRETASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I); wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula (I), or compositions including them, to a subject. The invention also comprises further embodiments of Formulas (II) and (III), intermediates and processes useful for the preparation of compounds of the invention.

Vinyl Cations, 38. Synthesis and Solvolysis of 3-Substituted 1-Cyclobutenyl Nonaflates

3-Methyl- (8a) and 3-cyclopropyl-1-cyclobutenyl nonaflate (8b) as well as 2-cyclopropyl-1-cyclobutenyl nonaflate (12) and the parent 1-cyclobutenyl nonaflate (3) were synthesized from the corresponding cyclobutanones and nonafluorobutanesulfonic anhydride (10).The solvolysis rates and the product compositions of the solvolyses in trifluoroethanol and trifluoroethanol/water mixtures were determined.All 1-cyclobutenyl nonaflates solvolyze via a SN1 mechanism involving the intermediate nonclassical 1-cyclobutenyl cation, which is additionally stabilized by the substituents in the 3-position.