1192010-29-9Relevant academic research and scientific papers
Biological evaluation of polyhalo 1,3-diazaheterocycle fused isoquinolin-1(2H)-imine derivatives
Huang, Chao,Yan, Sheng-Jiao,Zeng, Xiang-Hui,Dai, Xiao-Yang,Zhang, Yin,Qing, Chen,Lin, Jun
supporting information; experimental part, p. 1172 - 1180 (2011/04/19)
A series of polyhalo 1,3-diazaheterocycle fused isoquinolin-1(2H)-imines were evaluated in vitro against human tumour cell lines including A431, K562, HL60, HepG2 and Skov-3. As a result, some of the target compounds such as 5b, 5c, 5i, 5o, 6c, 6h and 7f
Facile route to 1,3-diazaheterocycle-fused [l,2b]isoquinolin-l(2H)-one derivatives via substitution-cyclization Reactions
Yan, Shengjiao,Huang, Chao,Su, Cunxiang,Ni, Yongfen,Lin, Jun
experimental part, p. 91 - 94 (2010/10/04)
The substitution-cyclization reaction of heterocyclic ketene aminals with polyhalo isophthalonitrile in the presence of I-BuOK to form 1,3-diazaheterocycle fused [1,2-fc]isoquinolin-l(2//)-imines, followed by hydrolysis with 1 N HCl, provides a concise and efficient route for the synthesis of highly functional polyhalo 1,3-diazaheterocycle fused [ 1,2-b]isoquinolin-1 (2H)-ones.
