1192145-70-2

Upstream product

• 17282-00-7 3-bromo-5-methylpyridin-2-amine 
• 87486-35-9 1-benzyl-3,5-dichloro-1H-pyrazin-2-one 
• 934542-54-8 1-benzyl-5-chloro-3-(5-methyl-3-trimethylsilanyl-ethynyl-pyridin-2-ylamino)-1H-pyrazin-2-one 
• 934542-55-9 7-benzyl-3-methyl-5-trimethylsilanyl-7,9-dihydro-dipyrido[2,3-b;4',3'-d]pyrrol-8-one 
• 934542-56-0 7-benzyl-5-iodo-3-methyl-7,9-dihydro-dipyrido[2,3-b;4',3'-d]pyrrol-8-one 
• 934542-53-7 1-benzyl-3-(3-bromo-5-methyl-pyridin-2-ylamino)-5-chloro-1H-pyrazin-2-one 
• 934542-57-1 7-benzyl-5-(3-ethanesulfonyl-phenyl)-3-methyl-7,9-dihydro-dipyrido[2,3-b;4',3'-d]pyrrol-8-one 
• 108-24-7 acetic anhydride 

Downstream Products

• 934542-58-2 5-(3-ethanesulfonyl-phenyl)-3-methyl-7,9-dihydro-dipyrido[2,3-b;4',3'-d]pyrrol-8-one 
• 934540-72-4 8-chloro-5-(3-ethanesulfonyl-phenyl)-3-methyl-9H-dipyrido[2,3-b;4',3'-d]pyrrole 

Relevant academic research and scientific papers

Intramolecular Diels-Alder synthesis of 7-aza-α-carboline compounds

An efficient, versatile, and scalable route for the synthesis of 7-aza-α-carboline compounds is described. The tricyclic system has been prepared from modified pyrazinones using a key intramolecular [4+2] Diels-Alder transformation.

KINASE INHIBITORS

Compounds are provided for use with kinases that comprise a compound selected from the rou consistin of:wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods an intermediates useful for making the compounds; and methods of using said compounds.