1192260-75-5Relevant academic research and scientific papers
Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium
Behnken, Swantje,Lincke, Thorger,Kloss, Florian,Ishida, Keishi,Hertweck, Christian
supporting information; experimental part, p. 2425 - 2428 (2012/04/23)
Anti-Terminator: Rise of the Molecules: Overexpression of an antiterminator gene (nusG) in Clostridium cellulolyticum induced the biosynthesis of the novel antibiotic closthioamide and related thioamides. This is the first successful genetic engineering of an anaerobe to trigger a cryptic pathway. Furthermore, synthetic probes provide valuable insights into the biogenetic relationship of the rare thioamide metabolites. Copyright
C-Glucosylflavonoid biosynthesis from 2-hydroxynaringenin by Desmodium uncinatum (Jacq.) (Fabaceae)
Hamilton, Mary L.,Caulfield, John C.,Pickett, John A.,Hooper, Antony M.
scheme or table, p. 5656 - 5659 (2011/02/24)
[2′,3′,5′,6′-2H4]-2-Hydroxynaringenin is synthesised and incubated with commercially available UDP-glucose and the crude protein extract from Desmoduim uncinatum leaves. The organic extract produces isotopically labelled [2′,3′,5′,6′-2H4]-vitexin and [2′,3′,5′,6′-2H4]-isovitexin. Repeating the experiment with denatured protein or replacing the 2-hydroxynaringenin with [2′,3′,5′,6′-2H4]-apigenin or [2′,3′,5′,6′-2H4]-naringenin results in no observable incorporation. 2-Hydroxynaringenin is therefore the substrate for C-glucosylflavonoid biosynthesis in D. uncinatum.
