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1192299-05-0

N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-2-trifluoromethylbenzenesulfonamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1192299-05-0 Structure

  • Basic information

    1. Product Name: N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-2-trifluoromethylbenzenesulfonamide
    2. Synonyms:
    3. CAS NO:1192299-05-0
    4. Molecular Formula:
    5. Molecular Weight: 504.486
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1192299-05-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-2-trifluoromethylbenzenesulfonamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-2-trifluoromethylbenzenesulfonamide(1192299-05-0)
    11. EPA Substance Registry System: N-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]-2-trifluoromethylbenzenesulfonamide(1192299-05-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1192299-05-0(Hazardous Substances Data)

1192299-05-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1192299-05-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,2,2,9 and 9 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1192299-05:
(9*1)+(8*1)+(7*9)+(6*2)+(5*2)+(4*9)+(3*9)+(2*0)+(1*5)=170
170 % 10 = 0
So 1192299-05-0 is a valid CAS Registry Number.

1192299-05-0Downstream Products

1192299-05-0Relevant articles and documents

Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as Novel AXL Kinase Inhibitors

Szabadkai, István,Torka, Robert,Garamv?lgyi, Rita,Baska, Ferenc,Gyulavári, Pál,Boros, Sándor,Illyés, Eszter,Choidas, Axel,Ullrich, Axel,órfi, László

, p. 6277 - 6292 (2018/07/05)

The overexpression of AXL kinase has been described in many types of cancer. Due to its role in proliferation, survival, migration, and resistance, AXL represents a promising target in the treatment of the disease. In this study we present a novel compound family that successfully targets the AXL kinase. Through optimization and detailed SAR studies we developed low nanomolar inhibitors, and after further biological characterization we identified a potent AXL kinase inhibitor with favorable pharmacokinetic profile. The antitumor activity was determined in xenograft models, and the lead compounds reduced the tumor size by 40% with no observed toxicity as well as lung metastasis formation by 66% when compared to vehicle control.

QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS

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Page/Page column 87, (2009/12/02)

The present invention relates to novel compounds which are inhibitors of receptor tyrosine kinases of the AXL receptor family. These compounds are suitable for the treatment or prevention of disorders associated with, accompanied by or caused by hyperfunc

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