1192490-69-9Relevant academic research and scientific papers
Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents
Vergelli, Claudia,Ciciani, Giovanna,Cilibrizzi, Agostino,Crocetti, Letizia,Di Cesare Mannelli, Lorenzo,Ghelardini, Carla,Guerrini, Gabriella,Iacovone, Antonella,Giovannoni, Maria Paola
, p. 6237 - 6245 (2015)
A number of heterocycles bearing an arylpiperazinylalkyl side chain and structurally related to the previously described lead ET1 (4-amino-6-methyl-2-[3-(4-p-tolylpiperazin-1-yl)propyl]-5-vinylpyridazin-3(2H)-one) was synthesized and tested for their anti
Further studies on arylpiperazinyl alkyl pyridazinones: Discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain
Biancalani, Claudio,Giovannoni, Maria Paola,Pieretti, Stefano,Cesari, Nicoletta,Graziano, Alessia,Vergelli, Claudia,Cilibrizzi, Agostino,Di Gianuario, Amalia,Colucci, Mariantonella,Mangano, Giorgina,Garrone, Beatrice,Polenzani, Lorenzo,Dal Piaz, Vittorio
experimental part, p. 7397 - 7409 (2010/06/13)
A number of pyridazinone derivatives bearing an arylpiperazinylalkyl chain were synthesized and tested icv in a model of acute nociception induced by thermal stimuli in mice (tail flick). The most interesting and potent compound in this series was 6a, whi
