17335-04-5Relevant articles and documents
2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists
Vergelli, Claudia,Schepetkin, Igor A.,Ciciani, Giovanna,Cilibrizzi, Agostino,Crocetti, Letizia,Giovannoni, Maria Paola,Guerrini, Gabriella,Iacovone, Antonella,Kirpotina, Liliya N.,Khlebnikov, Andrei I.,Ye, Richard D.,Quinn, Mark T.
, p. 2530 - 2543 (2016)
N-Formyl peptide receptors (FPRs: FPR1, FPR2, and FPR3) are G protein-coupled receptors that play key roles in modulating immune cells. FPRs represent potentially important therapeutic targets for the development of drugs that could enhance endogenous ant
Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors
Costantino, Luca,Rastelli, Giulio,Gamberini, M. Cristina,Giovannoni, M. Paola,Piaz, Vittorio Dal,Vianello, Paola,Barlocco, Daniela
, p. 1894 - 1900 (2007/10/03)
The isoxazolo-[3,4-d]-pyridazin-7-(6H)-one (2) and its corresponding open derivatives 5-acetyl-4-amino-(4-nitro)-6-substituted-3(2H)pyridazinones (3, 4) were used as simplified substrates for the synthesis of new aldose reductase inhibitors with respect t