17335-04-5Relevant academic research and scientific papers
2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists
Vergelli, Claudia,Schepetkin, Igor A.,Ciciani, Giovanna,Cilibrizzi, Agostino,Crocetti, Letizia,Giovannoni, Maria Paola,Guerrini, Gabriella,Iacovone, Antonella,Kirpotina, Liliya N.,Khlebnikov, Andrei I.,Ye, Richard D.,Quinn, Mark T.
, p. 2530 - 2543 (2016)
N-Formyl peptide receptors (FPRs: FPR1, FPR2, and FPR3) are G protein-coupled receptors that play key roles in modulating immune cells. FPRs represent potentially important therapeutic targets for the development of drugs that could enhance endogenous ant
Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents
Vergelli, Claudia,Ciciani, Giovanna,Cilibrizzi, Agostino,Crocetti, Letizia,Di Cesare Mannelli, Lorenzo,Ghelardini, Carla,Guerrini, Gabriella,Iacovone, Antonella,Giovannoni, Maria Paola
supporting information, p. 6237 - 6245 (2015/10/05)
A number of heterocycles bearing an arylpiperazinylalkyl side chain and structurally related to the previously described lead ET1 (4-amino-6-methyl-2-[3-(4-p-tolylpiperazin-1-yl)propyl]-5-vinylpyridazin-3(2H)-one) was synthesized and tested for their anti
Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors
Costantino, Luca,Rastelli, Giulio,Gamberini, M. Cristina,Giovannoni, M. Paola,Piaz, Vittorio Dal,Vianello, Paola,Barlocco, Daniela
, p. 1894 - 1900 (2007/10/03)
The isoxazolo-[3,4-d]-pyridazin-7-(6H)-one (2) and its corresponding open derivatives 5-acetyl-4-amino-(4-nitro)-6-substituted-3(2H)pyridazinones (3, 4) were used as simplified substrates for the synthesis of new aldose reductase inhibitors with respect t
