119260-93-4Relevant articles and documents
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells
Yu, Meng,Zeng, Minghui,Pan, Zhaoping,Wu, Fengbo,Guo, Li,He, Gu
supporting information, (2020/02/03)
In this study, a series of thieno [2,3-d]pyrimidine derivatives were designed, synthesized and evaluated as novel AKT1 inhibitors. In vitro antitumor assay results showed that compounds 9d-g and 9i potently suppressed the enzymatic activities of AKT1 and
Various synthetic routes to imidazothienopyrimidines and pyrimidothienopyrimidines in some cases annelated
Leistner, S.,Guetschow, M.,Vieweg, H.,Wagner, G.,Strohscheidt, Th.,Grupe, Renate
, p. 756 - 760 (2007/10/02)
The tricyclic or tetracyclic imidazothienopyrimidines and pyrimidothienopyrimidines were synthesized by three routes: Route A: Thieno1,3-thiazin-4-thiones E undergo the ring transformation with α,ω-diamino-alkanes to giv