1192740-50-3

Upstream product

• 6397-97-3 (R)-N-isobutylidene-1-phenylethylamine 
• 151-50-8 potassium cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 78-84-2 isobutyraldehyde 
• 91463-91-1 [2-Methyl-prop-(E)-ylidene]-((R)-1-phenyl-ethyl)-amine 

Downstream Products

• 72-18-4 L-valine 
• 42454-75-1 (S)-3-Methyl-2-((R)-1-phenyl-ethylamino)-butyric acid 

Relevant academic research and scientific papers

One-pot diastereoselective synthesis of α-aminonitriles from aldehydes, chiral amines, and trimethylsilyl cyanide under solvent-free conditions

Treatment of aliphatic and aromatic aldehydes with chiral amines and trimethylsilyl cyanide in the absence or in the presence of Lewis acids (including lithium perchlorate) under solvent-free conditions afforded the corresponding α-aminonitriles in good y

Lithium perchlorate/diethylether catalyzed aminocyanation of aldehydes

A simple and efficient one-pot method was developed to give α- aminonitriles from aldehydes + amines + TMSCN in LPDE. Optically active α- aminonitriles were snythesized by using (S)-(-)- or (R) (+) α- methylbenzylamine, (S)-(-) α-methylbenzylamine affords

Asymmetric Syntheses of Amino Acids by Addition of Cyanide to the Schiff Bases in the Presence of Cyanide-Modified Hemin-Copolymer

Sterically controlled addition reactions of CN group to the Schiff bases by using CN-modified hemin-copolymer were carried out, and the optical yields (80-95 e.e.) of the resulting amino acids were much higher than that obtained without hemin-copolymer.