1192750-33-6

Basic information

• Product Name: PE 154
• Synonyms: PE 154;2-(1,2,3,4-Tetrahydro-9-acridinyl)hydrazide-4-[[[7-(diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid
• CAS NO: 1192750-33-6
• Molecular Formula: C35H35N5O4
• Molecular Weight: 589.68
• Mol File: 1192750-33-6.mol
• Article Data: 1

Chemical Properties

• Appearance: white to light brown/
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble10mg/mL, clear (warmed)
• CAS DataBase Reference: PE 154(CAS DataBase Reference)
• NIST Chemistry Reference: PE 154(1192750-33-6)
• EPA Substance Registry System: PE 154(1192750-33-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1192750-33-6(Hazardous Substances Data)

Usage

Uses

PE 154 is a potent and fluorescent inhibitor of human acetylcholinesterase

Upstream product

• 1192750-32-5 2-(4-aminophenyl)-N'-1,2,3,4-tetrahydroacridin-9-ylacetohydrazide 
• 64369-55-7 7-(diethylamino)-4-hydroxy-2H-chromen-2-one 
• 122-51-0 orthoformic acid triethyl ester 

Relevant articles and documents

A Gorge-spanning, High-affinity cholinesterase inhibitor to explore β-amyloid plaques

Cholinesterases are involved in the pathological formation of β-amyloid plaques. To investigate this pathohistological hallmark of Alzheimer's disease we prepared a high-affinity, fluorescent cholinesterase inhibitor. Its fluorescence intensity was significantly enhanced upon binding to cholinesterases. Using this probe, brain samples from mice and humans affected by Alzheimer's disease were successfully analyzed for β-amyloid plaques. Unexpectedly, it was discovered, by competition experiments, that the compound binds to amyloid structures, rather than to cholinesterases inside of the plaques.