1192927-38-0

Basic information

• Product Name: (E)-1-(3-methyl-2-pyridinyl)-3-phenyl-2-propen-1-one
• Synonyms: (E)-1-(3-methyl-2-pyridinyl)-3-phenyl-2-propen-1-one
• CAS NO: 1192927-38-0
• Molecular Weight: 223.274
• Mol File: 1192927-38-0.mol

Chemical Properties

• CAS DataBase Reference: (E)-1-(3-methyl-2-pyridinyl)-3-phenyl-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(3-methyl-2-pyridinyl)-3-phenyl-2-propen-1-one(1192927-38-0)
• EPA Substance Registry System: (E)-1-(3-methyl-2-pyridinyl)-3-phenyl-2-propen-1-one(1192927-38-0)

Safety Data

• Hazardous Substances Data: 1192927-38-0(Hazardous Substances Data)

Upstream product

• 3430-17-9 2-bromo-3-picoline 
• 85279-30-7 1-(3-methylpyridin-2-yl)ethan-1-one 
• 100-52-7 benzaldehyde 

Downstream Products

• 1192927-41-5 (3-methyl-2-pyridinyl)(3-phenylbicyclo[2.2.1]hept-5-en-2-yl)methanone 

Relevant articles and documents

Turning Cucurbit[8]uril into a Supramolecular Nanoreactor for Asymmetric Catalysis

Chiral macromolecules have been widely used as synthetic pockets to mimic natural enzymes and promote asymmetric reactions. An achiral host, cucurbit[8]uril (CB[8]), was used for an asymmetric Lewis acid catalyzed Diels-Alder reaction. We achieved a remarkable increase in enantioselectivity and a large rate acceleration in the presence of the nanoreactor by using an amino acid as the chiral source. Mechanistic and computational studies revealed that both the amino acid-Cu2+ complex and the dienophile substrate are included inside the macrocyclic host cavity, suggesting that contiguity and conformational constraints are fundamental to the catalytic process and rate enhancement. These results pave the way towards new studies on asymmetric reactions catalyzed in confined achiral cavities.