85279-30-7

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(3-methyl-2-pyridinyl)(9CI) is used as an intermediate in the synthesis of various pharmaceuticals for its significant pharmacological properties. It plays a crucial role in the development of new drugs and medicinal compounds, contributing to the advancement of healthcare and treatment options.
Used in Pesticide Industry:
In the pesticide industry, Ethanone, 1-(3-methyl-2-pyridinyl)(9CI) is employed as a key component in the formulation of various pesticides. Its unique properties make it an effective ingredient in controlling pests and protecting crops, thereby ensuring food security and agricultural productivity.
Used in Organic Synthesis:
Ethanone, 1-(3-methyl-2-pyridinyl)(9CI) is utilized as a versatile building block in organic synthesis processes. Its unique structure allows for the creation of a wide range of organic compounds, contributing to the development of new materials, chemicals, and other products with diverse applications across various industries.

Upstream product

• 20970-75-6 2-cyano-3-methylpyridine 
• 74-88-4 methyl iodide 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 3430-17-9 2-bromo-3-picoline 
• 127-19-5 N,N-dimethyl acetamide 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1248195-40-5 ethyl 3-(3-methylpyridin-2-yl)-3-oxopropanoate 
• 1213130-14-3 (S)-1-(3-methylpyridin-2-yl)ethanamine 
• 220270-42-8 2-bromo-1-(3-methyl-pyridin-2-yl)-ethanone 
• 1192927-38-0 (E)-1-(3-methyl-2-pyridinyl)-3-phenyl-2-propen-1-one 
• 231296-38-1 2-bromoacetyl-3-methylpyridine hydrobromide 

Relevant academic research and scientific papers

BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME

The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor. In certain embodiments of the methods disclosed herein, the methods include administering to the subject a compound as disclosed herein and a peripherally acting P-blocker (PABRA).

Turning Cucurbit[8]uril into a Supramolecular Nanoreactor for Asymmetric Catalysis

Chiral macromolecules have been widely used as synthetic pockets to mimic natural enzymes and promote asymmetric reactions. An achiral host, cucurbit[8]uril (CB[8]), was used for an asymmetric Lewis acid catalyzed Diels-Alder reaction. We achieved a remarkable increase in enantioselectivity and a large rate acceleration in the presence of the nanoreactor by using an amino acid as the chiral source. Mechanistic and computational studies revealed that both the amino acid-Cu2+ complex and the dienophile substrate are included inside the macrocyclic host cavity, suggesting that contiguity and conformational constraints are fundamental to the catalytic process and rate enhancement. These results pave the way towards new studies on asymmetric reactions catalyzed in confined achiral cavities.

Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones

As the number of individuals affected with Alzheimer's disease (AD) increases and the availability of drugs for AD treatment remains limited, the need to develop effective therapeutics for AD becomes more and more pressing. Strategies currently pursued include inhibiting acetylcholinesterase (AChE) and targeting amyloid-β (Aβ) peptides and metal-Aβ complexes. This work presents the design, synthesis, and biochemical evaluation of a series of chalcones, and assesses the relationship between their structures and their ability to bind metal ions and/or Aβ species, and inhibit AChE/BChE activity. Several chalcones were found to exhibit potent disaggregation of pre-formed N-biotinyl Aβ1-42 (bioAβ42) aggregates in vitro in the absence and presence of Cu2+/Zn2+, while others were effective at inhibiting the action of AChE.

Volatile compounds formed from the pyrolysis of chitosan

Chitosan is a renewable resource for the production of nitrogen-containing aromatic heterocyclics. It was found that chitosan started to decompose and produce some volatile compounds at around 525 K in a nitrogen atmosphere, the volatiles were characterized by Fourier transform infrared spectrometer. The apparent activation energy for the thermal degradation of chitosan was determined. To further investigate the degradation, chitosan was pyrolyzed under vacuum at 553 K for 1 h, and the volatile compounds were analyzed by gas chromatography/mass spectrometry. The volatile compounds included aromatic heterocyclics such as pyrazines, pyridines, pyrroles and furans, and the pyrazines were the major products. The pyrolysis mechanism of chitosan was also proposed.

Compounds with Bridgehead Nitrogen

The position of conformational equilibra in 1,5-,1,6- and 1,8-dimethylperhydro-oxazolopyridines were determined by 1H NMR spectroscopy.The cis-(H-5,H-8a)-1,5-dimethylperhydro-oxazolopyridines adopted the trans fused conformation, as did the two isomers of cis-(H-1,H-8a)-1,6-dimethyl-perhydro-oxazolopyridine.In contrast, r-1,t-6,t-8a-1,6-dimethyl-perhydro-oxazolopyridine preferred the cis-fused conformation.Three of the 1,8-dimehylperhdro-oxazolopyridines adopted the trans-fused conformations (with distortion of the system in the case of the r-1,c-8,c-8a derivative) and the r-1,c-8,c-8a-1,8-dimethyl derivative adopted the cis-fused conformation.