119364-85-1

Basic information

• Product Name: (S)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol
• Synonyms: (S)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol
• CAS NO: 119364-85-1
• Molecular Weight: 307.823
• Mol File: 119364-85-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol(119364-85-1)
• EPA Substance Registry System: (S)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol(119364-85-1)

Safety Data

• Hazardous Substances Data: 119364-85-1(Hazardous Substances Data)

Usage

Description

(S)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol is a pharmaceutical compound belonging to the class of azole antifungals. It is characterized by its ability to inhibit the synthesis of ergosterol, which is a crucial component of the fungal cell membrane. This inhibition leads to the disruption of the fungal cell structure, ultimately resulting in the death of the fungus. (S)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol is effective against a broad spectrum of fungal infections and is utilized in various medical formulations.

Uses

Used in Pharmaceutical Industry:
(S)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol is used as an antifungal agent for the treatment of infections caused by fungi, including yeast infections. Its application is based on its ability to inhibit the synthesis of ergosterol, which is essential for the integrity of the fungal cell membrane.
Used in Antifungal Formulations:
(S)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol is used in various formulations such as oral tablets, creams, and injections to cater to different medical applications and patient needs. This versatility allows for targeted treatment of fungal infections in various parts of the body, enhancing the effectiveness of the compound in combating a wide range of fungal pathogens.
Used in Treatment of Specific Fungal Infections:
(S)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol is particularly effective against a wide range of fungal infections, making it a valuable asset in the treatment of conditions such as athlete's foot, ringworm, and other yeast-related infections. Its broad-spectrum activity ensures that it can be used to treat a variety of fungal infections, providing a reliable option for patients and healthcare providers.

Upstream product

• 41253-21-8 sodium triazole 
• 120687-98-1 Methanesulfonic acid (R)-2-[2-(4-chloro-phenyl)-ethyl]-2-hydroxy-3,3-dimethyl-butyl ester 
• 119298-84-9 Methanesulfonic acid (S)-2-[2-(4-chloro-phenyl)-ethyl]-2-hydroxy-3,3-dimethyl-butyl ester 
• 107534-96-3 tebuconazole 
• 119298-82-7 (S)-1-(4-Chloro-phenyl)-4,4-dimethyl-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-pentan-3-ol 
• 119364-84-0 (R)-1-(4-Chloro-phenyl)-4,4-dimethyl-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-pentan-3-ol 
• 120687-96-9 (R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-3,3-dimethyl-butyraldehyde 
• 120687-99-2 (S)-2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-3,3-dimethyl-butyraldehyde 
• 120687-97-0 (R)-2-[2-(4-Chloro-phenyl)-ethyl]-3,3-dimethyl-butane-1,2-diol 
• 119298-83-8 (S)-2-[2-(4-Chloro-phenyl)-ethyl]-3,3-dimethyl-butane-1,2-diol 
• 66346-01-8 1-(4-chlorophenyl)-4,4-dimethyl-pentan-3-one 
• 92572-79-7 2-(2,2-dimethylpropanoyl)-1,3-oxathiane 
• 6529-53-9 1-(2-bromoethyl)-4-chlorobenzene 

Relevant articles and documents

Preparation of a novel bridged bis(β-cyclodextrin) chiral stationary phase by thiol-ene click chemistry for enhanced enantioseparation in HPLC

A bridged bis(β-cyclodextrin) ligand was firstly synthesized via a thiol-ene click chemistry reaction between allyl-ureido-β-cyclodextrin and 4-4′-thiobisthiophenol, which was then bonded onto a 5 μm spherical silica gel to obtain a novel bridged bis(β-cyclodextrin) chiral stationary phase (HTCDP). The structures of HTCDP and the bridged bis(β-cyclodextrin) ligand were characterized by the 1H nuclear magnetic resonance (1H NMR), solid state 13C nuclear magnetic resonance (13C NMR) spectra spectrum, scanning electron microscope, elemental analysis, mass spectrometry, infrared spectrometry and thermogravimetric analysis. The performance of HTCDP in enantioseparation was systematically examined by separating 21 chiral compounds, including 8 flavanones, 8 triazole pesticides and 5 other common chiral drugs (benzoin, praziquantel, 1-1′-bi-2-naphthol, Tr?ger's base and bicalutamide) in the reversed-phase chromatographic mode. By optimizing the chromatographic conditions such as formic acid content, mobile phase composition, pH values and column temperature, 19 analytes were completely separated with high resolution (1.50-4.48), in which the enantiomeric resolution of silymarin, 4-hydroxyflavanone, 2-hydroxyflavanone and flavanone were up to 4.34, 4.48, 3.89 and 3.06 within 35 min, respectively. Compared to the native β-CD chiral stationary phase (CDCSP), HTCDP had superior enantiomer separation and chiral recognition abilities. For example, HTCDP completely separated 5 other common chiral drugs, 2 flavanones and 3 triazole pesticides that CDCSP failed to separate. Unlike CDCSP, which has a small cavity (0.65 nm), the two cavities in HTCDP joined by the aryl connector could synergistically accommodate relatively bulky chiral analytes. Thus, HTCDP may have a broader prospect in enantiomeric separation, analysis and detection. This journal is

Synthesis of magnetic multiwall carbon nanotubes for enantioseparation of three pesticide residues in fruits and vegetables by chiral liquid chromatography

In this study, magnetic multiwalled carbon nanotubes (MMWCNTs) were synthesized and used as adsorbent for preconcentration of chiral pesticide residues (including epoxiconazole, tebuconazole, and metalaxyl) in lettuce, cabbage, and apple. Several parameters affecting the treatment efficiency were investigated, including extraction solvent and absorption solvent. Under the optimal conditions, all three chiral pesticides showed decent enantiomeric separation (Rs?>?1.48). The linearity of each target was good with the correlation coefficient (r2) being greater than 0.9923. The average recoveries of the three spiked levels were 73.4% to 110.9% with repeatability (RSDr) less than 7.6%, and the limit of quantification of the method was 0.10 to 0.25?mg·kg?1. The results indicated that MMWCNTs had a good purifying effect, which can be applied as an effective pretreatment tool for the determination of residual chiral pesticides in fruits and vegetables.

Die Enantiomere des Azolfungizids HWG-1608 - asymmetrische Synthese eines 2-Hydroxyethyl-Azolfungizids

-