119378-93-7

Usage

Uses

Used in Chemical Synthesis:
BOC-3-(4-THIAZOLYL)-DL-ALANINE is used as a building block for the synthesis of peptides and other organic molecules, due to its unique structure and reactivity.
Used in Pharmaceutical Research:
BOC-3-(4-THIAZOLYL)-DL-ALANINE is used as a research compound for exploring its potential biological activities and pharmacological properties, which may contribute to the development of new drugs and therapies.
Used in Biological Research:
In the field of biology, BOC-3-(4-THIAZOLYL)-DL-ALANINE is utilized to study its interactions with biological systems and to understand its role in various biological processes.
Used in Material Science:
BOC-3-(4-THIAZOLYL)-DL-ALANINE may also find applications in material science, where its unique chemical structure could be leveraged to develop new materials with specific properties.

Upstream product

• 115-08-2 thiocarboxamide 
• 151215-36-0 (S)-5-Bromo-2-tert-butoxycarbonylamino-4-oxo-pentanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 129274-32-4 3-(4-thiazolyl)-DL-alanine dihydrochloride 
• 134038-96-3 (S)-2-Amino-3-thiazol-4-yl-propionic acid; hydrochloride 
• 34619-03-9 tert-butyldicarbonate 
• 119433-80-6 (2S)-2-amino-3-(thiazol-4-yl)propanoic acid 
• 801240-93-7 (S)-3-(4-thiazolyl)-2-benzoylaminopropanoic acid 
• 801240-92-6 (Z)-3-(4-thiazolyl)-2-benzoylaminoprop-2-enoic acid 
• 134038-94-1 diethyl 2-(2-bromoprop-2-en-1-yl)-2-acetamidopropanedioate 
• 151144-96-6 (S)-2-Amino-4-bromo-pent-4-enoic acid 
• 151144-95-5 (S)-2-Acetylamino-4-bromo-pent-4-enoic acid 
• 138742-45-7 ethyl 2-acetamido-4-bromopent-4-enoate 
• 151215-34-8 N-tert-butoxycarbonyl-L-2-amino-4-bromo-4-pentenoic acid 

Downstream Products

• 1449231-50-8 C₁₇H₂₁N₃O₃S 
• 1448429-44-4 (2S,3S)-ethyl 3-((S)-1-oxo-1-(phenylamino)-3-(thiazol-4-yl)propan-2-ylcarbamoyl)oxirane-2-carboxylate 
• 1448429-45-5 (2S,3S)-ethyl 3-((S)-1-(4-(4-fluorophenyl)thiazol-2-ylamino)-1-oxo-3-(thiazol-4-yl)propan-2-ylcarbamoyl)oxirane-2-carboxylate 
• 1448429-46-6 (2S,3S)-ethyl 3-((S)-1-(4-(4-ethynylphenyl)thiazol-2-ylamino)-1-oxo-3-(thiazol-4-yl)propan-2-ylcarbamoyl)oxirane-2-carboxylate 
• 1448429-00-2 (2S,3S)-3-((S)-1-oxo-1-(phenylamino)-3-(thiazol-4-yl)propan-2-ylcarbamoyl)oxirane-2-carboxylic acid 
• 1448429-01-3 (2S,3S)-3-((S)-1-(4-(4-fluorophenyl)thiazol-2-ylamino)-1-oxo-3-(thiazol-4-yl)propan-2-ylcarbamoyl)oxirane-2-carboxylic acid 
• 1448429-02-4 (2S,3S)-3-((S)-1-(4-(4-ethynylphenyl)thiazol-2-ylamino)-1-oxo-3-(thiazol-4-yl)propan-2-ylcarbamoyl)oxirane-2-carboxylic acid 
• 131896-42-9 (2R)-2-amino-3-(thiazol-4-yl)propanoic acid 
• 1416469-39-0 tert-butyl [(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]carbamate 
• 1416469-40-3 (4aS,8aR)-2-{1-[(2R)-2-amino-3-(1,3-thiazol-4-yl)propanoyl]piperidin-4-yl}-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one hydrochloride 

Relevant academic research and scientific papers

N-(Boc)-L-(2-bromoallyl)-glycine: A versatile intermediate for the synthesis of optically active unnatural amino acids

N(Boc)-L-(2-bromoallyl)-glycine (1) was synthesized from diethylacetamidomalonate and 2,3-dibromopropene in a one-pot procedure (75% overall yield). The enantiomers were efficiently separated via a tandem biocatalytic kinetic hydrolytic resolution. 1 was

Enantioselective synthesis of (S)-3-(4-thiazolyl)-2-tert- butoxycarbonylaminopropionic acid: A chiral building block for renin inhibitor

(S)-3-(4-Thiazolyl)-2-tert-butoxycarbonylaminopropionic acid (6), an important structural constituent of the renin inhibitor, has been synthesized from (Z)-3-(4-thiazolyl)-2-benzoylaminoprop-2-enoic acid (4b) by enantioselective hydrogenation using the Ru

Antiparkinsonism drugs

A compound represented by the formula: wherein A is thiazolyl or the like, X is a bond or the like, m is an integer of 0 to 4, Y is optionally substituted alkyl or the like, Z is a substituent represented by the formula: wherein R3 is hydrogen atom or the like, R4 and R5 are each independently hydrogen atom or the like, W is —(CH2)n— (n is 0,1,2 or 3) or the like, a prodrug thereof, its pharmaceutically acceptable salt, or its solvate is useful as a composition for prevention or treatment of Parkinson's disease.

Peptide derivatives having thiazolyl-alanine residue

A peptide derivation of the formula (I) or its pharmaceutically acceptable salt or hydrate thereof is disclosed. These compounds have superior ability over thyroid stimulating hormone (TRH) and its derivatives to activate the central nervous system, such as, for example, sustained acetylcholine releasing action, anti-reserpine action and locomotor increment.

ENCAPSULATED RENIN INHIBITOR COMPOSITION

A pharmaceutical composition comprising a solution of a tenin inhibitor of the formula: STR1 wherein R 1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-1-oxo-4-piperazinyl, 2-oxo-4-piperazinyl, 4-morpholinyl, 4-thiomorpholinyl or 1-methyl-4-homopiperazinyl; R 2 is benzyl, p-methoxybenzyl, 2-phenylethyl, 1-naphthylmethyl or 2-naphthylmethyl;R 3 is 4-thiazolyl, 2-amino-4-thiazolyl, 2-thiazolyl, 5-thiazolyl, 1-pyrazolyl, 3-pyrazolyl, 1-imidazolyl, n-propyl, isopropyl, CH 3 S--or CH 3 SCH 2--;R 4 is loweralkyl or cyclopropyl;R 5 is hydrogen or loweralkyl; andX is CH 2 or NH; or a pharmaceutically acceptable salt, ester or prodrug thereof in a pharmaceutically acceptable solvent, said solution being encapsulated in a soft elastic gelatin capsule.

Psoriasis treatment

The present invention relates to the use of renin inhibitors and to renin inhibitor compositions for treatment of psoriasis.

PEPTIDYL AMINODIOL RENIN INHIBITORS

A renin inhibiting compound having an aminodiol functional group is useful for treating hypertension, congestive heart failure and glaucoma and inhibits retroviral protease.

Synthesis of N-(tert-Butoxycarbonyl)-3-(4-thiazolyl)-L-alanine

Efficient syntheses of N-(tert-butoxycarbonyl)-3-(4-thiazolyl)-L-alanine (11) are described.