1194-78-1

Basic information

• Product Name: 2,4,5-Triamino-6-chloropyrimidine
• Synonyms: 2,4,5-Triamino-6-chloropyrimid;2,4,5-Triamino-6-chloropyrimidine;6-Chloro-2,4,5-pyrimidinetriamine;6-ChloropyriMidine-2,4,5-triaMine;2,4,5-Triamino-6-hydroxypyrimidine dihydrochloride
• CAS NO: 1194-78-1
• Molecular Formula: C₄H₆ClN₅
• Molecular Weight: 159.58
• Product Categories: FINE Chemical & INTERMEDIATES
• Mol File: 1194-78-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 480 °C at 760 mmHg
• Flash Point: 244.1 °C
• Appearance: /
• Density: 1.685g/cm³
• Vapor Pressure: 2.25E-09mmHg at 25°C
• Refractive Index: 1.788
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2,4,5-Triamino-6-chloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-Triamino-6-chloropyrimidine(1194-78-1)
• EPA Substance Registry System: 2,4,5-Triamino-6-chloropyrimidine(1194-78-1)

Safety Data

• Hazardous Substances Data: 1194-78-1(Hazardous Substances Data)

Usage

General Description

2,4,5-Triamino-6-chloropyrimidine is a type of chemical compound that belongs to the class of organic compounds known as triaminopyrimidines. These are organic compounds containing a pyrimidine moiety that is substituted by three amine groups. Its systematic name is 4-amino-2,6-diaminopyrimidin-5-ol. In its pure form, it appears as a dark brown solid and has a molar mass of 190.62 g/mol. It has potential use in various fields like medicine, agriculture etc. However, like all chemicals, it needs to be handled appropriately ensuring that safety protocols are strictly followed.

InChI:InChI=1/C4H6ClN5/c5-2-1(6)3(7)10-4(8)9-2/h6H2,(H4,7,8,9,10)

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 5822-69-5 6-chloro-5-<(4-chlorophenyl)azo>-2,4-pyrimidinediamine 
• 55583-59-0 2,5-diamino-4,6-dichloropyrimidine 

Downstream Products

• 88780-84-1 7-chloro-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine 
• 10310-21-1 2-amino-6-chloropurine 

Relevant articles and documents

2-amino-6-chloropurine as well as synthesis method, intermediate and application thereof

The invention belongs to the technical field of medicines and in particular relates to 2-amino-6-chloropurine as well as a synthesis method, an intermediate and application thereof. The synthesis method of the 2-amino-6-chloropurine comprises the following steps: performing a primary reaction, namely mixing ethyl cyanoacetate, chloroformamidine hydrochloride, liquid ammonia and sodium to implementa reaction so as to generate an intermediate; performing a secondary reaction, namely mixing the intermediate with formic acid to implement a reaction; adding a sodium hydroxide solution into the product of the secondary reaction till alkali; and performing filtering and drying, so as to obtain 2-amino-6-chloropurine. Raw materials are low in price and easy to obtain, reaction steps are small, the reaction time is short, a large amount of wastewater is not generated, and industrial production can be facilitated.

COMPOUNDS FOR TREATING CYSTIC FIBROSIS

The present invention relates to compounds of Formula (I) or pharmaceutically acceptable enantiomers, salts, solvates or prodrugs thereof. The invention further relates to the use of the compounds of Formula (I) for the treatment of cystic fibrosis. The invention also relates to a process for manufacturing compounds of Formula (I).

Bis (hydroxymethyl) cyclobutyl triazolopyrimidines

Antiviral activity is exhibited by compounds having the formula STR1 and its pharmaceutically acceptable salts wherein R1 is STR2 R6 is hydrogen, alkyl, substituted alkyl, or aryl; and R7 and R8 are independentl