1194044-26-2

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-methyl-propane-2-sulfinic acid [1-(5-bromo-2-fluoro-phenyl)-ethylidene]-amide is used as a potential drug candidate for the development of medications targeting various medical conditions. Its unique structure and properties make it a valuable compound for research and development in the pharmaceutical field.
Used in Cancer Treatment:
In the field of oncology, (R)-2-methyl-propane-2-sulfinic acid [1-(5-bromo-2-fluoro-phenyl)-ethylidene]-amide is used as a potential therapeutic agent for the treatment of various types of cancer. Its specific interactions with cellular targets and its ability to modulate signaling pathways make it a promising candidate for further investigation into its anticancer properties.
Used in Infectious Disease Treatment:
(R)-2-methyl-propane-2-sulfinic acid [1-(5-bromo-2-fluoro-phenyl)-ethylidene]-amide is also used as a potential therapeutic agent in the treatment of infectious diseases. Its unique chemical structure allows it to target specific pathogens and disrupt their mechanisms, offering a new approach to combatting infections.

Upstream product

• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 552331-15-4 1-(5-bromo-2-fluorophenyl)ethan-1-ol 
• 198477-89-3 1-(5-bromo-2-fluorophenyl)ethan-1-one 
• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 

Downstream Products

• 1374001-18-9 (S)-1-(5-bromo-2-fluoro-phenyl)-1-methyl-but-3-enylamine 
• 1374001-19-0 C₁₆H₂₁BrFNO₂ 
• 1374001-20-3 tert-butyl [(2S)-2-(5-bromo-2-fluorophenyl)-4-oxobutan-2-yl]carbamate 
• 1374001-21-4 C₁₇H₂₁BrFN₃O₂ 
• 1374001-22-5 C₁₂H₁₃BrFN₃ 
• 1374001-23-6 C₁₃H₁₂BrFN₄ 
• 1374001-10-1 C₁₈H₁₅F₂N₅ 
• 1374001-17-8 N-[(1S)-1-(5-bromo-2-fluoro-phenyl)-1-methyl-but-3-enyl]-2-methyl-propane-2-sulfinamide 

Relevant academic research and scientific papers

A Single Quadrupole Compact Mass Spectrometer Enabling Early Stage Synthetic Optimization of Verubecestat (MK-8931)

A low-cost compact mass spectrometer was effectively utilized for identifying and tracking process impurities in the early stage development of a multistep synthetic protocol used to prepare the verubecestat drug substance. Process optimizations were infl

2,3,4,5-TETRAHYDROPYRIDIN-6-AMINE AND 3,4-DIHYDRO-2H-PYRROL-5-AMINE COMPOUND INHIBITORS OF BETA-SECRETASE

The present invention relates to 2,3,4,5-tetrahydropyridin-6-amine and 3,4- dihydro-2H-pyrrol-5-amine compound inhibitors of beta-secretase having the structure shown in Formula (I), wherein the radicals are as defined in the specification. The invention

2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use

In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein each of the variables shown in the formula are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including Alzheimer's disease, are also disclosed.

S-IMINO-S-OXO IMINOTHIAZINE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides provides certain S-imino-S-oxo iminothiazine compounds, including compounds Formula (I): or a tautomers and/or stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein RN, R1A, R1B, R2, R3, R4, ring A, RA, m, L1-, and RL are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and may be useful for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

FUSED AMINODIHYDROPYRIMIDINE DERIVATIVE

The present invention provides, for example, the following compound: wherein ring A is a substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, X1—X2═X3 is CR5—CR6═CRs

BACE INHIBITORS

The present invention provides BACE inhibitors of Formula I: methods for their use, and intermediates and methods for their preparation.