1194091-69-4

Upstream product

• 306934-99-6 2-amino-4-(4-bromo-phenyl)-thiophene-3-carboxylic acid ethyl ester 
• 6419-36-9 3-pyridineacetic acid hydrochloride 

Downstream Products

• 1190766-23-4 3-(4-bromophenyl)-4-hydroxy-5-(pyridin-3-yl)-6,7-dihydro-thieno[2,3-b]pyridin-6-one 
• 1194090-94-2 4-hydroxy-3-(3'-hydroxymethylbiphenyl-4-yl)-5-(pyridine-3-yl)-6,7-dihydro-thieno[2,3-b]pyridin-6-one 
• 1194090-93-1 4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-5-(pyridine-3-yl)-6,7-dihydro-thieno[2,3-b]pyridin-6-one 

Relevant academic research and scientific papers

THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS

The present invention relates to compounds of formula (I) wherein R1, R2 and B1, B2 are as defined in claim 1, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diseases and disorders modulated by AMP agonists. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).