119422-40-1Relevant academic research and scientific papers
Efficient synthesis of biologically important chiral 2-alkylamino benzoxazinones
Mohapatra, Debendra K.,Datta, Apurba
, p. 2527 - 2530 (1997)
A novel general method has been developed for the synthesis of various amino acid derived chiral 2-substituted benzoxazinones, known inhibitors of standard serine proteases of the chymotrypsin superfamily.
First total synthesis of versicotide A, B and C
Posada, Laura,Davyt, Danilo,Serra, Gloria
, p. 43653 - 43659 (2020)
The syntheses of versicotides A-C, natural products containing anthranilic acid and NMe-Ala, were achieved by solid phase peptide synthesis on 2-chlorotrityl resin followed by solution phase macrocyclization. Using an oxyma additive, the difficult coupling reactions to the deactivated aromatic amine of o-aminobenzoic acid, were performed in high yield, avoiding anthranilic rearrangements or side reactions. This journal is
Synthesis and anticancer activity of conformationally constrained Smac mimetics containing pseudo β turns
Baravkar, Sachin B.,Wagh, Mahendra A.,Paul, Debasish,Santra, Manas,Sanjayan, Gangadhar J.
supporting information, p. 3473 - 3476 (2018/08/24)
Herein, we report synthesis and in vitro anticancer activity of conformationally constrained Smac mimetics containing reverse turn inducing motifs “Ant-Pro” and “sAnt-Pro”. The synthesis of Smac analogs with diverse hydrophobic groups at the C-
New routes to 1,4-benzodiazepin-2,5-diones
Akssira,Boumzebra,Kasmi,Dahdouh,Roumestant,Viallefont
, p. 9051 - 9060 (2007/10/02)
1,4-benzodiazepin-2,5-diones have been synthesized in good overall yields by two routes, the first one by cyclisation of dipeptides prepared from Boc anthranilic acid and α-amino acid methyl esters, the second one by reaction of N-carboxy α-amino acid anhydrides with Boc anthranilic acid.
