199392-31-9Relevant academic research and scientific papers
Construction of N-Boc-2-Alkylaminoquinazolin-4(3H)-Ones via a Three-Component, One-Pot Protocol Mediated by Copper(II) Chloride that Spares Enantiomeric Purity
Li, Xiaoyu,Golden, Jennifer E.
supporting information, p. 1638 - 1645 (2021/02/09)
Chiral 2-alkylquinazolinones are key synthetic intermediates, but their preparation in high optical purity is challenging. Thus, a multicomponent procedure integrating anthranilic acids, N-Boc-amino acids, and amines in the presence of methanesulfonyl chl
First total synthesis of versicotide A, B and C
Posada, Laura,Davyt, Danilo,Serra, Gloria
, p. 43653 - 43659 (2020/12/25)
The syntheses of versicotides A-C, natural products containing anthranilic acid and NMe-Ala, were achieved by solid phase peptide synthesis on 2-chlorotrityl resin followed by solution phase macrocyclization. Using an oxyma additive, the difficult coupling reactions to the deactivated aromatic amine of o-aminobenzoic acid, were performed in high yield, avoiding anthranilic rearrangements or side reactions. This journal is
Efficient synthesis of biologically important chiral 2-alkylamino benzoxazinones
Mohapatra, Debendra K.,Datta, Apurba
, p. 2527 - 2530 (2007/10/03)
A novel general method has been developed for the synthesis of various amino acid derived chiral 2-substituted benzoxazinones, known inhibitors of standard serine proteases of the chymotrypsin superfamily.
