119439-55-3Relevant academic research and scientific papers
Optimization of subsite binding to the β5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: Syntheses and cellular properties of potent, selective proteasome inhibitors
Rydzewski, Robert M.,Burrill, Leland,Mendonca, Rohan,Palmer, James T.,Rice, Mark,Tahilramani, Ram,Bass, Kathryn E.,Leung, Ling,Gjerstad, Erik,Janc, James W.,Pan, Lin
, p. 2953 - 2968 (2007/10/03)
Beginning with the peptide sequence Cbz-Ile-Glu(OtBu)-Ala-Leu found in PSI (3), a series of vinyl sulfones (VS) were synthesized for evaluation as inhibitors of the chymotrypsin-like activity of the 20S proteasome. Variations at the key P3 position confir
ATRIOPEPTINS. II. SYNTHESIS OF N-TERMINAL FRAGMENTS
Ovchinnikov, Mikhail V.,Bespalova, Zhanna D.,Molokoedov, Aleksandr S.,Revenko, Inna V.,Sepetov, Nikolai F.,et al
, p. 784 - 795 (2007/10/02)
Peptides, corresponding to the N-terminal sequence in atriopeptins, were synthesized by classical methods of peptide chemistry in solutions.The obtained peptides were characterized by various physicochemical methods.The scheme and methods of the synthesis are discussed.
