119491-09-7Relevant articles and documents
Bioinspired nanophotosensitizers: Synthesis and characterization of porphyrin-noble metal nanoparticle conjugates
Bhaumik, Jayeeta,Gogia, Gitanjali,Kirar, Seema,Vijay, Lekshmi,Thakur, Neeraj S.,Banerjee, Uttam C.,Laha, Joydev K.
, p. 724 - 731 (2016)
A methodology to enhance biological delivery of photosensitizers by incorporating them into nanomaterials has been developed. In order to prepare photosensitizer nanoconjugates as biocompatible and selective probes, initially, bioconjugatable porphyrinic
Mechanofluorochromic properties of fluorescent molecules based on a dicyanomethylene-4: H -pyran and indole isomer containing different alkyl chains via an alkene module
Qian, Lebin,Zhou, Yibin,Liu, Miaochang,Huang, Xiaobo,Wu, Ge,Gao, Wenxia,Ding, Jinchang,Wu, Huayue
, p. 42180 - 42191 (2017)
A series of 3-, 4-, and 5-position indole-substituted dicyanomethylene-4H-pyran (I3PM, I4PM, and I5PM) derivatives with different alkyl chains were synthesized and their mechanofluorochromic (MFC) properties were investigated. Compared with the alkyl chains, the isomerization of the indole unit plays a more important role in regulating the MFC properties of these compounds. The increase of the alkyl chain length and the isomerization of the alkyl chain are favorable to the effective mechanofluorochromism of the I3PM derivatives, however, the former exhibits the opposite effect on that of the I4PM derivatives. The opposite alkyl length-dependent MFC behavior is closely related to the degree of distortion of the molecular conformation, namely the more twisted the molecular conformation, the more pronounced the MFC phenomenon. In particular, the introduction of the alkyl chains is completely detrimental to the MFC properties of the I5PM derivatives. X-Ray diffraction experiments indicate that the MFC properties of some of these compounds should be mainly attributed to the transformation from a crystalline state to an amorphous state because the weak intermolecular interactions and loose molecular packing modes in their solid-state samples can be easily damaged under external force stimuli as revealed by the single crystal X-ray diffraction analysis.
Synthesis of 3-Formylindoles via Electrochemical Decarboxylation of Glyoxylic Acid with an Amine as a Dual Function Organocatalyst
Lin, Dian-Zhao,Huang, Jing-Mei
supporting information, p. 5862 - 5866 (2019/08/26)
A new method for 3-formalytion of indoles has been developed through electrochemical decarboxylation of glyoxylic acid with the amine as a dual function organocatalyst. The amine facilitated both the electrochemical decarboxylation and the nucleophilic reaction efficiently, whose loading can be as low as 1 mol %. This protocol has a broad range of functional group tolerance under ambient conditions. The gram-scale experiment has shown great potential in the synthetic application of this strategy.
α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands
Ann, Jihyae,Czikora, Agnes,Saini, Amandeep S.,Zhou, Xiaoling,Mitchell, Gary A.,Lewin, Nancy E.,Peach, Megan L.,Blumberg, Peter M.,Lee, Jeewoo
supporting information, p. 6261 - 6276 (2018/06/11)
Diacylglycerol-lactones have proven to be a powerful template for the design of potent ligands targeting C1 domains, the recognition motif for the cellular second messenger diacylglycerol. A major objective has been to better understand the structure activity relations distinguishing the seven families of signaling proteins that contain such domains, of which the protein kinase C (PKC) and RasGRP families are of particular interest. Here, we synthesize a series of aryl- and alkyl-substituted diacylglycerol-lactones and probe their relative selectivities for RasGRP3 versus PKC. Compound 96 showed 73-fold selectivity relative to PKCα and 45-fold selectivity relative to PKC? for in vitro binding activity. Likewise, in intact cells, compound 96 induced Ras activation, a downstream response to RasGRP stimulation, with 8-29 fold selectivity relative to PKCδ S299 phosphorylation, a measure of PKCδ stimulation.
