119561-19-2

Basic information

• Product Name: N-(1-phenyl-2,2,2-trifluoroisopropylidene)benzylamine
• Synonyms: N-(1-phenyl-2,2,2-trifluoroisopropylidene)benzylamine
• CAS NO: 119561-19-2
• Molecular Weight: 263.262
• Mol File: 119561-19-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N-(1-phenyl-2,2,2-trifluoroisopropylidene)benzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-phenyl-2,2,2-trifluoroisopropylidene)benzylamine(119561-19-2)
• EPA Substance Registry System: N-(1-phenyl-2,2,2-trifluoroisopropylidene)benzylamine(119561-19-2)

Safety Data

• Hazardous Substances Data: 119561-19-2(Hazardous Substances Data)

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 100-46-9 benzylamine 
• 52826-45-6 (benzylimino)triphenylphosphorane 

Downstream Products

• 1035954-38-1 benzyl-[2,2,2-trifluoro-1-phenylethyl]amine 
• 1589570-35-3 (S)-N-(2,2,2-trifluoro-1-phenylethyl)acetamide 
• 22038-85-3 (R)-(-)-2,2,2-Trifluoro-1-phenylethylamine 
• 1453102-07-2 C₁₅H₁₄F₃N 
• 13652-09-0 (RS)-1-phenyl-2,2,2-trifluoroethylamine hydrochloride 
• 119561-20-5 N-benzylidene(1-phenyl-2,2,2-trifluoroethyl)amine 
• 51586-24-4 1-amino-2,2,2-trifluoro-1-phenylethane 
• 1098215-29-2 N₁,N₂-dibenzyl-3,3,3-trifluoro-2-phenyl-N₂-(trifluoroacetyl)alaninamide 
• 1098215-44-1 ethyl N-benzyl-3,3,3-trifluoro-2-phenyl-N-(trifluoroacetyl)alanylglycinate 

Relevant articles and documents

Solid fly-ash:h2so4 catalyzed microwave assisted solvent-free condensation:synthesis of some trifluoromethyl-imines

Good yield of trifluoromethyl-imines have been synthesized by Fly-ash:H2SO4 catalyzed condensation of anilines and phenyl trifluoromethyl ketone in microwave irradiation under solvent free conditions.

Chemoenzymatic dynamic kinetic resolution of α-trifluoromethylated amines: Influence of substitutions on the reversed stereoselectivity

Enzymatic resolution of α-trifluoromethylated amines via kinetic resolution (KR), dynamic kinetic resolution (DKR) employing CALB-Pd/Al 2O3, and a one-pot sequential process of KR/DKR/KR was investigated comparatively for the first time. Although CALB-catalyzed KR of α-trifluoromethylated amines with substituents of methyl (1a), isopropyl (1c), phenyl (1d) and benzyl group (1e) can provide good stereoselectivity factors E from 31 to >200 respectively, DKR and sequential process of KR/DKR/KR possess better practical application potential because of the higher conversion (62%-84%) and the similar enantiomeric excesses (90%-99%). The enantiopreference and inversion for the α-trifluoromethylated amines displayed by CALB were observed and explained by docking modes. Namely, for 1,1,1-trifluoro-2-propylamine (1a), the product amide with R-configuration was obtained, and the enantiopreference was converted to S for the amines (1b-1e) with substituents larger than methyl group. The catalysts recycle, and scale-up experiments were demonstrated successfully. All these results indicated the high efficiency and green feature of this enzymatic process, and its application significance.

Diastereoselective alkylation of glycinates by assistance of intramolecular potassium-fluorine interactions

A study was conducted to demonstrate diatereoselective alkylation of glycinates by assistance of intermolecular potassium-fluorine interactions. Preparation of the starting materials for the investigations was carried out from the readily available fluorinated acetophenones. The investigations focused on finding appropriate alkylation conditions after their transformation to the corresponding enolates. The representative starting material was subjected to a solution of a base in THF at -78°C to generate the enolate. The model electrophile, BnBr was introduced in the investigations after stirring for 0.5 hours at the same temperature.