119580-41-5 Usage
General Description
2(S)-2-Trifluoromethylpyrrolidine is a chemical compound with the molecular formula C5H8F3N. It is a white to light yellow liquid with a boiling point of 83-85°C. 2(S)-2-TRIFLUOROMETHYLPYRROLIDINE is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various pharmaceuticals and agrochemicals. It is also known for its use as a reagent in organic synthesis. Additionally, 2(S)-2-Trifluoromethylpyrrolidine is used as a chiral auxiliary in asymmetric synthesis, due to its ability to impart chirality to certain reactions. It is important to handle this compound with caution, as it may cause skin and eye irritation, and should be kept away from sources of ignition.
Check Digit Verification of cas no
The CAS Registry Mumber 119580-41-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,5,8 and 0 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 119580-41:
(8*1)+(7*1)+(6*9)+(5*5)+(4*8)+(3*0)+(2*4)+(1*1)=135
135 % 10 = 5
So 119580-41-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H8F3N/c6-5(7,8)4-2-1-3-9-4/h4,9H,1-3H2/t4-/m0/s1
119580-41-5Relevant articles and documents
(5S)-5-(trifluoromethyl)pyrrolidin-2-one as a promising building block for fluoroorganic chemistry
Bezdudny, Andrii V.,Alekseenko, Anatoliy N.,Mykhailiuk, Pavel K.,Manoilenko, Olga V.,Shishkin, Oleg V.,Pustovit, Yurii M.
, p. 1782 - 1785 (2011)
Pyroglutamic acid smoothly reacts with sulfur tetrafluoride at room temperature to afford enantiomerically pure (5S)-5-(trifluoromethyl)pyrrolidin- 2-one (92 % yield, >99 % ee). Representative one-step transformations of 1 provided both γ-(S)-trifluoromethyl GABA and (2S)-2-(trifluoromethyl) pyrrolidine on a multigram scale. Pyroglutamic acid smoothly reacts with sulfur tetrafluoride at room temperature to afford enantiomerically pure (5S)-5-(trifluoromethyl)pyrrolidin-2-one (1; 92 %yield, >99 % ee). Representative one-step transformations of 1 provided γ-(S)- trifluoromethyl GABA and (2S)-2-(trifluoromethyl)pyrrolidine on a multigram scale. Copyright
FLUORODEOXYGENATION OF PROLINE, OPTICALLY ACTIVE 2-TRIFLUOROMETHYLPYRROLIDINE, AND ITS CHROMOPHORIC DERIVATIVES
Shustov, G. V.,Denisenko, S. N.,Chervin I. I.,Kostyanovskii, R. G.
, p. 1422 - 1427 (2007/10/02)
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