119580-41-5 Usage
Uses
Used in Pharmaceutical Industry:
2(S)-2-Trifluoromethylpyrrolidine is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into the design of new drugs, potentially enhancing their efficacy and selectivity.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 2(S)-2-Trifluoromethylpyrrolidine serves as a key component in the creation of agrochemicals, contributing to the development of more effective and targeted pesticides and other agricultural products.
Used as a Reagent in Organic Synthesis:
Beyond its applications in specific industries, 2(S)-2-Trifluoromethylpyrrolidine is also utilized as a reagent in organic synthesis. Its reactivity and stability make it a valuable tool for chemists in a wide range of organic reactions.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
2(S)-2-Trifluoromethylpyrrolidine is recognized for its role as a chiral auxiliary in asymmetric synthesis. Its ability to impart chirality to certain reactions is crucial for the production of enantiomerically pure compounds, which are essential in many pharmaceutical and chemical applications.
Safety Considerations:
It is important to handle 2(S)-2-Trifluoromethylpyrrolidine with care due to its potential to cause skin and eye irritation. Additionally, it should be stored and used away from sources of ignition to prevent accidents. Proper safety measures and personal protective equipment are recommended during its use to ensure the safety of individuals and the integrity of the chemical processes involved.
Check Digit Verification of cas no
The CAS Registry Mumber 119580-41-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,5,8 and 0 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 119580-41:
(8*1)+(7*1)+(6*9)+(5*5)+(4*8)+(3*0)+(2*4)+(1*1)=135
135 % 10 = 5
So 119580-41-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H8F3N/c6-5(7,8)4-2-1-3-9-4/h4,9H,1-3H2/t4-/m0/s1
119580-41-5Relevant academic research and scientific papers
Bezdudny, Andrii V.,Alekseenko, Anatoliy N.,Mykhailiuk, Pavel K.,Manoilenko, Olga V.,Shishkin, Oleg V.,Pustovit, Yurii M.
, p. 1782 - 1785 (2011)
Pyroglutamic acid smoothly reacts with sulfur tetrafluoride at room temperature to afford enantiomerically pure (5S)-5-(trifluoromethyl)pyrrolidin- 2-one (92 % yield, >99 % ee). Representative one-step transformations of 1 provided both γ-(S)-trifluoromethyl GABA and (2S)-2-(trifluoromethyl) pyrrolidine on a multigram scale. Pyroglutamic acid smoothly reacts with sulfur tetrafluoride at room temperature to afford enantiomerically pure (5S)-5-(trifluoromethyl)pyrrolidin-2-one (1; 92 %yield, >99 % ee). Representative one-step transformations of 1 provided γ-(S)- trifluoromethyl GABA and (2S)-2-(trifluoromethyl)pyrrolidine on a multigram scale. Copyright
Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives
Bugera, Maksym,Trofymchuk, Serhii,Tarasenko, Karen,Zaporozhets, Olga,Pustovit, Yurii,Mykhailiuk, Pavel K.
, p. 16105 - 16115 (2019/12/24)
A practical method for the synthesis of functionalized aliphatic trifluoromethyl-substituted derivatives from aliphatic acids is developed. The transformation proceeds with sulfur tetrafluoride in the presence of water as a key additive. Compared to previous methods, the reaction gives products with full retention of stereo- and absolute configuration of chiral centers.
