1195986-76-5Relevant academic research and scientific papers
Diversity synthesis of N-substituted 2-amino-l,6-naphthyridine derivatives under microwave irradiation
Han, Zheng-Guo,Miao, Chun-Bao,Shi, Feng,Ning, Ma.,Zhang, Ge,Tu, Shu-Jiang
, p. 16 - 19 (2010)
A sequential three-component reaction of 3, 5-diarylidenepiperidm-4-one, malononitrile, and amine (such as aromatic amine, cyclopropanamine, and NH 4OAc) in acetic acid under microwave irradiation has been developed. In this one-pot reaction, a series of new N-substituted 2-amino-l, 6-naphthyridine derivatives were synthesized with excellent yields. This method has the advantages of operational simplicity and increased safety for small-scale fast synthesis of N-aryl 2-amino-l, 6-naphthyridines for biomedical screening.
