1196498-83-5Relevant articles and documents
Isoleucine-catalyzed direct asymmetric aldol addition of enolizable aldehydes
Rohr, Kerstin,Mahrwald, Rainer
supporting information; experimental part, p. 2180 - 2183 (2012/07/13)
Isoleucine-catalyzed direct enantioselective aldol additions between enolizable aldehydes are reported. Intermediate acetal structures dictate the configurative outcome and were supported by a hydrogen bond. This direct isoleucine-catalyzed aldol addition represents a welcome complement to both proline- and histidine-catalyzed aldol additions of enolizable aldehydes.
Histidine-catalyzed asymmetric aldol addition of enolizable aldehydes: Insights into its mechanism
Scheffler, Ulf,Mahrwald, Rainer
experimental part, p. 2310 - 2330 (2012/05/20)
Extensive studies of asymmetric cross-aldol addition between enolizable aldehydes are described and provide a deeper insight into histidine-catalyzed aldol additions. In particular, aspects of enantio- as well as diastereoselectivity of these reactions are discussed. Rules and predictions of configurative outcome are explained by using different transition-state models. These discussions are confirmed by extensive computations.