1196872-66-8Relevant articles and documents
On Demand Attachment and Detachment of rac-2-Br-DMNPA Tailoring to Facilitate Chemical Protein Synthesis
Chen, Junlang,He, Chunmao,Zhang, Yuqi
, p. 6477 - 6481 (2021/08/30)
Herein, we developed a bifunctional reagent rac-2-Br-DMNPA 2 for the late-stage protection of peptide cysteine. Through the identification of its t-Bu ester 1 as a more competent form under ligation conditions, facile N-terminal and side-chain caging for
Photorelease of tyrosine from α-carboxy-6-nitroveratryl (αCNV) derivatives
Russell, Alexander G.,Sadler, Matthew J.,Laidlaw, Helen J.,Gutierrez-Loriente, Agustin,Wharton, Christopher W.,Carteau, David,Bassani, Dario M.,Snaith, John S.
experimental part, p. 556 - 563 (2012/06/30)
The synthesis of photolabile tyrosine derivatives protected on the phenolic oxygen by the α-carboxy-6-nitroveratryl (αCNV) protecting group is described. The compounds undergo rapid photolysis at wavelengths longer than 300 nm to liberate the corresponding phenol in excellent yield (quantum yield for the deprotection of tyrosine = 0.19). Further protection of caged tyrosine is possible, yielding N-Fmoc protected derivatives suitable for direct incorporation of caged tyrosine in solid-phase peptide synthesis.
Wavelength-selective photoactivatable protecting groups for thiols
Kotzur, Nico,Briand, Benoit,Beyermann, Michael,Hagen, Volker
supporting information; experimental part, p. 16927 - 16931 (2010/04/04)
We developed and characterized efficient, remarkably water-soluble photolabile protecting groups for thiols based on 2-nitrobenzyl and (coumarin-4-yl)methyl chromophores, among them two new ones. The protecting groups allow, due to their different absorpt
