73357-18-3

Usage

InChI:InChI=1/C10H11NO6/c1-16-8-3-6(4-10(12)13)7(11(14)15)5-9(8)17-2/h3,5H,4H2,1-2H3,(H,12,13)/p-1

Upstream product

• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 76936-55-5 4-allyl-1,2-dimethoxy-5-nitrobenzene 
• 50546-76-4 (4,5-dimethoxy-2-nitro-phenyl)-acetic acid amide 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 860189-86-2 (4,5-dimethoxy-2-nitro-phenyl)-pyruvic acid 
• 7722-84-1 dihydrogen peroxide 
• 5663-56-9 2-(3,4-dimethoxyphenyl)acetamide 
• 872273-69-3 (4-benzyloxy-3-methoxy-phenyl)-pyruvic acid 
• 29973-91-9 4-benzyloxy-3-methoxyphenylacetic acid 
• 77-78-1 dimethyl sulfate 
• 85580-22-9 3,4-dimethoxy-2-nitrophenylacetic acid benzhydryl ester 
• 714251-84-0 (4-hydroxy-5-methoxy-2-nitro-phenyl)-acetic acid 

Downstream Products

• 6286-64-2 5,6-dimethoxy-2-indolinone 
• 6286-65-3 6,7-dimethoxy-2-methyl-4H-benzo[d] [1,3]oxazin-4-one 
• 118109-34-5 (2-amino-4,5-dimethoxy-phenyl)-acetic acid 
• 105997-76-0 4,5-dihydroxy-2-nitrophenylacetic acid 
• 876479-47-9 (4,5-dimethoxy-2-nitro-phenyl)-acetic acid-(2,3-dimethoxy-phenethylamide) 
• 73357-23-0 2-(4,5-dimethoxy-2-nitrophenyl)ethan-1-ol 
• 53602-52-1 4,5-dimethoxy-2-nitrophenylacetic acid chloride 
• 85580-22-9 3,4-dimethoxy-2-nitrophenylacetic acid benzhydryl ester 
• 2982-53-8 methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate 
• 1196872-66-8 tert butyl (4,5-dimethoxy-2-nitrophenyl)acetate 
• 1233875-84-7 4,5-dimethoxy-2-nitrophenylacetic acid allyl ester 
• 117197-25-8 (3,4-dimethoxy-6-nitro-phenyl)-acetic acid anilide 
• 1174219-22-7 rac-α-tert-butoxycarbonyl-4,5-dimethoxy-2-nitrobenzyl bromide 

Relevant academic research and scientific papers

On Demand Attachment and Detachment of rac-2-Br-DMNPA Tailoring to Facilitate Chemical Protein Synthesis

Herein, we developed a bifunctional reagent rac-2-Br-DMNPA 2 for the late-stage protection of peptide cysteine. Through the identification of its t-Bu ester 1 as a more competent form under ligation conditions, facile N-terminal and side-chain caging for

α-Carboxy-6-nitroveratryl: A photolabile protecting group for carboxylic acids

(Figure presented) The synthesis of a new photolabile protecting group for carboxylic acids, α-carboxy-6-nitroveratryl (αCNV), is described. Bromide 3, prepared in four steps from 3,4-dimethoxyphenylacetic acid, was used to alkylate carboxylic acids under mild conditions in good yield. Palladium-catalyzed deallylation afforded the acids 4a-h, which underwent rapid and quantitative photolysis at wavelengths longer than 300 nm to liberate the carboxylic acid in good to quantitative yield. The rate of photolysis and quantum yield were determined to be 325 s-1 and 0.17.

Wavelength-selective photoactivatable protecting groups for thiols

We developed and characterized efficient, remarkably water-soluble photolabile protecting groups for thiols based on 2-nitrobenzyl and (coumarin-4-yl)methyl chromophores, among them two new ones. The protecting groups allow, due to their different absorpt

INDOLINONE DERIVATIVES AS RECEPTOR TYROSINE KINASE IHIBITORS

Novel derivatives of compound (E)-1,3-dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-2H-indol-2-one and the use thereof for the preparation of medicaments for the treatment of tumors in which the tyrosine kinase activity proteins Met, PDGF-R, FGF-R1

Indolinone derivatives

Novel derivatives of compound (E)-1,3-dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-2H-indol-2-one and the use thereof for the preparation of medicaments for the treatment of tumors in which the tyrosine kinase activity proteins Met, PDGF-R, FGF-R1

Nitrobenzene "Caged" Compounds as Irreversible Photoreductants: A Rational Approach to Studying Photoinduced Intermolecular Electron-Transfer Reactions in Proteins

Nitrobenzene "caged" compounds are well-known for their use in delivering biologically active substrates to a reaction mixture after photoexcitation.We have discovered that they also behave as photoreductants from the triplet state after photoexcitation.T

3-tetrazolylthiomethyl cephalosporin antibiotics

A compound of the formula (II): STR1 and pharmaceutically acceptable salts an in vivo hydrolysable esters are described as is their preparation and use as antibacterial agents.

Aminotetralin derivatives

This invention related to new aminotetralin derivatives of formula I STR1 wherein STR2 B is methylene or, when A is --CH2 --CH2 --, --CH=CH--, --NH--CO-- or --CH2 --CO--, B can also be carbonyl or thiocarbonyl; E is a C2 -C4 straight-chain alkylene, optionally substituted by a C1 -C3 alkyl, or is 2-hydroxy-n-propylene, 2-hydroxy-n-butylene or 3-hydroxy-n-butylene; R1 is hydrogen, fluorine, chlorine, bromine, trifluoromethyl, nitro, amino, C1 -C3 alkylamino, C1 -C3 dialkylamino, C1 -C3 alkyl, C1 -C3 alkylthio, hydroxy, C1 -C3 alkoxy or phenyl C1 -C3 alkoxy; R2 is hydrogen, chlorine, bromine, hydroxy, C1 -C3 alkoxy phenyl C1 -C3 alkoxy, or C1 -C3 alkyl or, together with R1, can be a C1 -C2 alkylenedioxy; R3 and R4 are each independently selected from hydrogen, fluorine, chlorine, bromine, C1 -C3 alkyl, hydroxy, C1 -C3 alkoxy, nitro, amino, C1 -C3 alkylamino, or C1 -C3 dialkylamino, or together can be methylenedioxy; and R5 is hydrogen, C3 -C5 alkenyl, C1 -C3 alkyl, or phenyl C1 -C3 alkyl, and nontoxic, pharmaceutically acceptable addition salts thereof which have valuable pharmacological properties, particularly a long-lasting heart rate lowering effect and the effect of reducing the O2 requirement of the heart.

The deblocking of cephalosporin benzhydryl esters with formic acid

The synthesis of benzhydryl esters of cephalosporin derivatives (4-6) and removal of the benzhydryl protecting group with formic acid are described.