1196979-22-2Relevant academic research and scientific papers
Synthesis of benzazepines by gold-catalysed reactions of N-allenylamides
Gonzalez-Gomez, Alvaro,Dominguez, Gema,Perez-Castells, Javier
scheme or table, p. 5057 - 5062 (2010/02/28)
The gold-catalysed reactions of alleneamides give different products depending on the substrate and the reaction conditions. In particular, N-(2-alkynylphenyl)-N-allenyltosylamides give benzazepines when using gold(III) catalysts in the presence of nucleophiles. This sequential process may follow two different reaction pathways, and these are discussed. Metal coordination to the alkyne followed by nucleophilic attack of the aliene and trapping of the intermediate with NuH accounts for the formation of 4, but coordination to the aliene and addition of NuH to give 3, which can decompose into other products and also form 4, is postulated as a better explanation for these results.
