1197-12-2

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4,5-dichloro-1H-pyrrole-2-carboxylate is used as a precursor in the synthesis of various drugs. Its unique structure and reactivity allow for the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 4,5-dichloro-1H-pyrrole-2-carboxylate is utilized as a starting material for the production of pesticides. Its chemical properties enable the creation of effective pest control agents.
Used in Research and Development Laboratories:
Methyl 4,5-dichloro-1H-pyrrole-2-carboxylate is also employed in research settings for the exploration and creation of new molecules with potential biological activity. Its versatility and utility in organic chemistry make it a popular choice for scientists working on innovative chemical compounds.

InChI:InChI=1/C6H5Cl2NO2/c1-11-6(10)4-2-3(7)5(8)9-4/h2,9H,1H3

Upstream product

• 106116-36-3 L-4,4,5-Trichlor-3,4-dihydro-2H-pyrrol-2-carbonsaeure-methylester 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 50371-51-2 2,2,2-trichloro-1-(4,5-dichloro-1H-pyrrol-2-yl)ethan-1-one 
• 124-41-4 sodium methylate 
• 72652-31-4 2,2,2-trichloro-1-(4-chloro-1H-pyrrol-2-yl)ethan-1-one 
• 106115-96-2 L-1-Benzhydryl-5-oxoprolin-methylester 
• 103322-12-9 methyl (S)-1-benzoyl-2-oxopyrrolidine-5-carboxylate 
• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 1194-96-3 4-chloro-1H-pyrrole-2-carboxylic acid methyl ester 

Downstream Products

• 1416956-56-3 methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1-[(4-methyl-benzene)sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate 
• 1416956-57-4 (3-bromo-4,5-dichloro-1-[2-(hydroxymethyl)-1-[(4-methylbenzene)-sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrol-2-yl)methanol 
• 1416956-58-5 3-bromo-4,5-dichloro-1-(2-formyl-1-[(4-methylbenzene)sulfonyl]-1H-pyrrol-3-yl)-1H-pyrrole-2-carbaldehyde 
• 1416956-60-9 3-bromo-4,5-dichloro-2-[(2-methoxyphenyl)carbonyl]-1-(2-[(2-methoxyphenyl)carbonyl]-1H-pyrrol-3-yl)-1H-pyrrole 
• 1416956-65-4 C₃₁H₂₃BrCl₂N₂O₆S 
• 1416956-61-0 3-bromo-4,5-dichloro-1-(4,5-dichloro-2-[(2-methoxyphenyl)carbonyl]-1H-pyrrol-3-yl)-2-[(2-methoxyphenyl)carbonyl]-1H-pyrrole 

Relevant academic research and scientific papers

Racemic marinopyrrole B by total synthesis

The first synthesis of marinopyrrole B, which is highly active against methicillin-resistant Staphylococcus aureus, is described. The route involved constructing a pyrrole ring on the nitrogen of a 3-bromo-4,5-dichloropyrrole by N-alkylation with a special Michael acceptor having an allylic leaving group; the second pyrrole ring was then formed by a Paal-Knorr reaction.

4-OXO-4,5-DIHYDROPYRROLO[1,2-A] QUINOXALINE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE(PARP)

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP- ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusio

PYRROLO[1,2-A]PYRAZIN-1(2H)-ONE AND PYRROLO[1,2-D][1,2,4]TRIAZIN-1(2H)-ONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE(PARP)

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP- ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.

The regioselective synthesis of aryl pyrroles

Pyrrole is a unique aromatic molecule as it can readily undergo substitution at all five positions but obtaining the desired regioisomer can prove difficult to control. We now report our results on the regioselective arylation of pyrrole, utilizing select

Amino Acids, 9 - Reactions of 5-Oxoproline Derivatives with Phosphorus Pentachloride - Synthesis of Chloro-pyrrole-2-carboxylic Acid Derivatives

N-Benzyl-4,5-dichloro-1H-pyrrole-2-carboxylic esters 6 are formed from N-benzyl-5-oxoproline esters 5 and PCl5 via differently chlorinated intermediates.The N-benzhydryl- L-3 and N-acyl-5-oxoproline esters L-4, on the other hand, suffer cleavage of the N-substituent in the course of this reaction sequence to give L-4,4,5-trichloro-3,4-dihydro-2H-pyrrole-2-carboxylic esters 18, which are dehydrohalogenated in the presence of base, yielding 4,5-dichloro-1H-pyrrole-2-carboxylic esters 20.These reactions provide the best access to 4,5-dichloro-1H-pyrrole-2-carboxylic acid derivatives which, in turn, can serve as precursors in the synthesis of pyoluteorin type compounds.