1194-96-3

Basic information

• Product Name: methyl 4-chloro-1H-pyrrole-2-carboxylate
• Synonyms: methyl 4-chloro-1H-pyrrole-2-carboxylate
• CAS NO: 1194-96-3
• Molecular Formula: C₆H₆ClNO₂
• Molecular Weight: 159.571
• Mol File: 1194-96-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 100-101°
• Boiling Point: 278.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.356±0.06 g/cm3(Predicted)
• PKA: 13.58±0.50(Predicted)
• CAS DataBase Reference: methyl 4-chloro-1H-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-chloro-1H-pyrrole-2-carboxylate(1194-96-3)
• EPA Substance Registry System: methyl 4-chloro-1H-pyrrole-2-carboxylate(1194-96-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1194-96-3(Hazardous Substances Data)

Usage

General Description

Methyl 4-chloro-1H-pyrrole-2-carboxylate is a chemical compound with the molecular formula C7H7ClNO2. It is a pyrrole derivative that contains a methyl ester and a chloro group. methyl 4-chloro-1H-pyrrole-2-carboxylate is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of dyes and pigments. Methyl 4-chloro-1H-pyrrole-2-carboxylate is a white to off-white crystalline solid with a melting point of 82-84°C. It is important to handle this compound with caution as it may cause irritation to the eyes and skin upon contact, and harmful if ingested or inhaled.

Upstream product

• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 72652-31-4 2,2,2-trichloro-1-(4-chloro-1H-pyrrol-2-yl)ethan-1-one 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 91323-04-5 2-methoxycarbonyl-2,4-dichloro-5-pyrroline 
• 186581-53-3 diazomethane 

Downstream Products

• 1197-12-2 4,5-Dichlor-1H-pyrrol-2-carbonsaeure-methylester 
• 791780-57-9 1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester 
• 1057653-42-5 N-[2-({[(4-chloro-1H-pyrrol-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide 
• 62569-72-6 4-Chloro-1-phenethyl-1H-pyrrole-2-carboxylic acid 
• 86288-66-6 4-Chloro-1-phenethyl-1H-pyrrole-2-carbonyl chloride 
• 628733-86-8 1-{[N-benzyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrimidoyl]-amino}-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester 
• 906672-43-3 [1-(3-benzyl-6-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 628733-88-0 (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine 
• 628733-87-9 (+/-)-2-(1-aminopropyl)-3-benzyl-6-chloro-3-H-pyrrolo[2,1-f][1,2,4]triazine-4-one 
• 86289-11-4 4-Chloro-1-(2-oxo-2-phenyl-ethyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 86307-69-9 4-Chloro-1-phenethyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 86288-98-4 7-Chloro-3-phenyl-3,4-dihydro-pyrrolo[2,1-c][1,4]oxazin-1-one 

Relevant articles and documents

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JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are pyrrolotriazine compounds for treatment of JAK kinase, including JAK2 kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

The regioselective synthesis of aryl pyrroles

Pyrrole is a unique aromatic molecule as it can readily undergo substitution at all five positions but obtaining the desired regioisomer can prove difficult to control. We now report our results on the regioselective arylation of pyrrole, utilizing select