1194-96-3

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-chloro-1H-pyrrole-2-carboxylate is used as a key intermediate in the synthesis of various pharmaceuticals for its versatile chemical properties and reactivity, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, methyl 4-chloro-1H-pyrrole-2-carboxylate serves as an intermediate in the production of agrochemicals, aiding in the development of pesticides and other agricultural chemicals to enhance crop protection and yield.
Used in Dye and Pigment Production:
Methyl 4-chloro-1H-pyrrole-2-carboxylate is utilized as a building block in the creation of dyes and pigments, providing a range of colors and properties for various applications in industries such as textiles, plastics, and inks.

Upstream product

• 186581-53-3 diazomethane 
• 91323-04-5 2-methoxycarbonyl-2,4-dichloro-5-pyrroline 
• 67-56-1 methanol 
• 72652-31-4 2,2,2-trichloro-1-(4-chloro-1H-pyrrol-2-yl)ethan-1-one 
• 124-41-4 sodium methylate 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 

Downstream Products

• 86288-98-4 7-Chloro-3-phenyl-3,4-dihydro-pyrrolo[2,1-c][1,4]oxazin-1-one 
• 86307-69-9 4-Chloro-1-phenethyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 86289-11-4 4-Chloro-1-(2-oxo-2-phenyl-ethyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 791780-57-9 1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester 
• 1197-12-2 4,5-Dichlor-1H-pyrrol-2-carbonsaeure-methylester 
• 1057653-42-5 N-[2-({[(4-chloro-1H-pyrrol-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide 
• 62569-72-6 4-Chloro-1-phenethyl-1H-pyrrole-2-carboxylic acid 
• 86288-66-6 4-Chloro-1-phenethyl-1H-pyrrole-2-carbonyl chloride 
• 628733-86-8 1-{[N-benzyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrimidoyl]-amino}-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester 
• 906672-43-3 [1-(3-benzyl-6-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 628733-88-0 (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine 
• 628733-87-9 (+/-)-2-(1-aminopropyl)-3-benzyl-6-chloro-3-H-pyrrolo[2,1-f][1,2,4]triazine-4-one 

Relevant academic research and scientific papers

TRI-CYCLE COMPOUND AND APPLICATIONS THEREOF

Disclosed in the present invention are a compound represented by formula (I), a tautomer thereof or a pharmaceutically acceptable salt, and applications thereof in the preparation of drugs for treating HBV-related diseases.

JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are pyrrolotriazine compounds for treatment of JAK kinase, including JAK2 kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

PYRROLO[1,2-A]PYRAZIN-1(2H)-ONE AND PYRROLO[1,2-D][1,2,4]TRIAZIN-1(2H)-ONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE(PARP)

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP- ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.

The regioselective synthesis of aryl pyrroles

Pyrrole is a unique aromatic molecule as it can readily undergo substitution at all five positions but obtaining the desired regioisomer can prove difficult to control. We now report our results on the regioselective arylation of pyrrole, utilizing select

Chlorination of N-Tritylproline Methyl Ester

The reaction of N-tritylproline methyl ester with tert-butyl hypochlorite gave 2,4-dichloro-2-methoxycarbonyl-5-pyrroline, which is readily converted to 2-methoxycarbonyl-4-chloropyrrole.The intermediate products were identified by chromatographic mass spectrometry when the reaction was carried out at low temperatures.