119741-56-9Relevant articles and documents
Alkylation Studies with 5-Cyano-1H-pyrazole-4-carboxylic Acid, Ethyl Ester
Beck, James R.,Aikins, James,Lynch, Michael P.,Rizzo, John R.,Tao, Eddie V.P.
, p. 3 - 6 (2007/10/02)
5-Cyano-1H-pyrazole-4-carboxylic acid, ethyl ester (1) was regioselectively alkylated at N-1 by tertiary carbocations utilizing sulfuric acid catalysis and relatively mild conditions.In the presence of boron trifluoride, the alkylation occured regioselectively at N-2.Reaction of 1 with alkyl halides under basic conditions resulted in mixture of the two isomers with alkylation at N-2 predominating.