119741-57-0Relevant academic research and scientific papers
Transition-Metal-Free [3 + 2] Cycloaddition of Nitroolefins and Diazoacetonitrile: A Facile Access to Multisubstituted Cyanopyrazoles
Chen, Zhen,Zhang, Yue,Nie, Jing,Ma, Jun-An
supporting information, p. 2120 - 2124 (2018/04/14)
A transition-metal-free [3 + 2] cycloaddition reaction between nitroolefins and diazoacetonitrile (N2CHCN) is described. This protocol exhibits several merits including simple starting materials, mild reaction conditions, broad substrate scope, good yields, and regioselectivities. The one-pot three-component reaction of nitroolefins with diazoacetonitrile (N2CHCN) and alkyl halides is also developed, thus delivering a series of multisubstituted cyanopyrazoles in good to high yields.
THERAPEUTIC INHIBITORY COMPOUNDS
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Paragraph 00389, (2018/03/26)
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.
Reaction of 4-Hydroxy-5-oximino-3-thiophenecarboxylates with Hydrazines. Formation of Pyrazolylthiohydroxamic Acids
Robey,Alt,Van Meter
, p. 413 - 428 (2007/10/03)
The reactions of 4-hydroxy-5-oximino-3-thiophenecarboxylates with hydrazine and substituted hydrazines have been investigated. The products of the reactions have been shown to be pyrazole-3- or 5-thiohydroxamic acids rather than the hydrazones previously described by Benary and Silberstrom. Two alternate mechanisms are proposed which account for the regiochemical outcome. The structures of the pyrazole-3- and 5-thiohydroxamic acids and corresponding nitriles have been proven by independent synthesis, comparison to known compounds, and by proton and carbon magnetic resonance and long range HETCOR experiments.
1,3-Dipolar Cycloaddition as Applied to the Synthesis of 5-Cyano-1-(1,1-dimethylethyl)-N-methyl-1H-pyrazole-4-carboxamide
Tao, E. V. P.,Rizzo, John R.,Aikins, James
, p. 1655 - 1656 (2007/10/02)
The title compound was synthesized via 1,3-dipolar cycloaddition of diazoacetonitrile and diethyl fumarate.
A Novel Regioselective t-Butylation as Applied to the Synthesis of 5-Cyano-1-(1,1-dimethylethyl)-N-methyl-1H-pyrazole-4-carboxamide
Tao, E. V. P.,Aikins, J.,Rizzo, J.,Beck, J. R.,Lynch, M. P.
, p. 1293 - 1294 (2007/10/02)
The title compound was synthesized in a regiocontrolled way from 5-cyano-1H-pyrazole-4-carboxylic acid, ethyl ester (5) with isobutylene, p-toluenesulfonic acid and methylamine.
