1197422-65-3Relevant academic research and scientific papers
Morita-Baylis-Hillman adducts as building blocks of heterocycles: a simple approach to 4-substituted pyrazolones, and mechanism investigation via ESI-MS(/MS)
Barcelos, Rosimeire C.,Zeoly, Lucas A.,Rodrigues, Manoel T.,Ferreira, Bruno R. V.,Eberlin, Marcos N.,Coelho, Fernando
, p. 1557 - 1570 (2015)
Abstract We describe herein an efficient approach for the preparation of 4-substituted 2,3-dihydro-1H-pyrazol-3-ones starting from Morita-Baylis-Hillman adducts. These heterocycles were obtained in two or three steps as single isomers with moderate to goo
Spirocyclohexadienones as an uncommon scaffold for acetylcholinesterase inhibitory activity
Almeida, Wanda P.,Coelho, Fernando,Gomes, Ralph C.,Sakata, Renata P.
, p. 373 - 382 (2019/07/12)
Background: The most important cause of dementia affecting elderly people is the Alzheimer’s disease (AD). Patients affected by this progressive and neurodegenerative disease have severe memory and cognitive function impairments. Some medicines used for t
An easy access to halogenated and non-halogenated spiro-hexadienones
Martins, Lucimara J.,Ferreira, Bruno R.V.,Almeida, Wanda P.,Lancellotti, Marcelo,Coelho, Fernando
, p. 5264 - 5267 (2015/01/09)
We describe an improved protocol for the synthesis of spiro-hexadienones from Morita-Baylis-Hillman adducts. Solvent modification and temperature resulted in a significant increase in the yield. This protocol was used to synthesize mono- and dibrominated spiro-hexadienones in good overall yields. This report is the first to describe the synthesis of halogenated spiro-hexadienones from Morita-Baylis-Hillman adducts.
Highly functionalized spirocyclohexadienones from Morita-Baylis-Hillman adducts
Pirovani, Rodrigo V.,Ferreira, Bruno R. V.,Coelho, Fernando
scheme or table, p. 2333 - 2337 (2009/12/08)
Spirohexadienone is a structural moiety present in several biologically active natural products isolated both from terrestrial and marine natural sources. This structural moiety is commonly and strictly related to the biological properties exhibited by th
