1198348-26-3Relevant academic research and scientific papers
A general and highly efficient method for the construction of aryl-substituted N-heteroarenes
Liu, Chun,Han, Na,Song, Xiaoxiao,Qiu, Jieshan
, p. 5548 - 5551 (2010)
A general, simple and highly efficient method has been developed for the Pd(OAc)2-catalyzed ligand-free and aerobic Suzuki reaction of N-heteroaryl halides, which is strongly dependent on the molecular structure of solvent. A general, simple and highly efficient method has been developed for the Pd(OAc)2-catalyzed ligand-free and aerobic Suzuki reaction of N-heteroaryl halides including 2-pyridyl bromides, 3-pyridyl bromides, 3-quinolyl bromides, 5-pyrimidyl bromides and 2-pyrazyl chloride, which is strongly dependent on the molecular structure of solvent.
A general palladium-catalyzed cross-coupling of aryl fluorides and organotitanium (IV) reagents
He, Xiao-Yun
, p. 823 - 832 (2021/07/19)
Pd(OAc)2/1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxy-piperidine was demonstrated to effectively catalyze cross-coupling of aryl fluoride and aryl(alkyl) titanium reagent. Both electron-deficient and electron-rich aryl fluoride can react effectively with nucleophile and provide extensive functional groups tolerance. 2-Arylated product was realized by selective activation of the C–F bond. Graphic abstract: [Figure not available: see fulltext.].
Evaluation of Improved Glycogen Synthase Kinase-3α Inhibitors in Models of Acute Myeloid Leukemia
Neumann, Theresa,Benajiba, Lina,G?ring, Stefan,Stegmaier, Kimberly,Schmidt, Boris
, p. 8907 - 8919 (2015/12/09)
The challenge for glycogen synthase kinase-3 (GSK-3) inhibitor design lies in achieving high selectivity for one isoform over the other. The therapy of certain diseases, such as acute myeloid leukemia (AML), may require α-isoform specific targeting. The s
Systematic evaluation of HOMO energy levels for efficient dye regeneration in dye-sensitized solar cells
Funaki, Takashi,Otsuka, Hiromi,Onozawa-Komatsuzaki, Nobuko,Kasuga, Kazuyuki,Sayama, Kazuhiro,Sugihara, Hideki
supporting information, p. 15945 - 15951 (2015/03/03)
Thirty ruthenium complexes of the types [Ru(tctpy)(C^N)NCS] and [Ru(tctpy)(N^O)NCS] (C^N = cyclometalating ligand and N^O = pyridinecarboxylate and its derivatives) were synthesized and evaluated to identify the highest occupied molecular orbital (HOMO) energy level (EHOMO) for efficient dye regeneration in dye-sensitized solar cells. EHOMOof these complexes was systematically tuned by changing the electron-donating ability of the C^N and N^O ligands. For complexes with an EHOMOin the potential range more negative than 0.5 V vs. a saturated calomel electrode (SCE), the incident photon-to-current conversion efficiency (IPCE) increased with a positive shift in EHOMObut could not exceed 70%, suggesting that rapid dye regeneration is difficult. On the other hand, high IPCEs above 70% were often observed for complexes with an EHOMOmore positive than 0.5 V vs. SCE. It is thus concluded that there is a threshold for efficient electron transfer near 0.5 V vs. SCE (ΔG2≈ 0.3 eV) for the series of these sensitizers. This journal is
A fast and oxygen-promoted protocol for the ligand-free Suzuki reaction of 2-halogenated pyridines in aqueous media
Liu, Chun,Yang, Weibo
supporting information; experimental part, p. 6267 - 6269 (2010/02/16)
A fast protocol has been developed for the construction of 2-aryl-substituted pyridine derivatives by the oxygen-promoted, ligand-free, Pd(OAc)2-catalyzed Suzuki reaction of 2-halogenated pyridines in aqueous isopropanol.
