112176-19-9

Upstream product

• 546-68-9 titanium(IV) isopropylate 
• 106-38-7 para-bromotoluene 
• 20717-86-6 triisopropoxytitanium(IV) chloride 
• 696-61-7 4-tolylmagnesium chloride 

Downstream Products

• 57833-68-8 BrTi(OiPr)3 
• 112176-17-7 4'-methyl-1,2,3,4-tetrahydro-1,1'-biphenyl 
• 2749-96-4 4-methylphenylallene 
• 1517-63-1 (R)-(4-Methylphenyl)phenylmethanol 
• 24218-12-0 (S)-(4-Methylphenyl)phenylmethanol 
• 1198348-26-3 5-fluoro-2-(4-methylphenyl)pyridine 
• 1099613-36-1 2-[2-(4-methylphenyl)ethynyl]naphthalene 
• 82404-39-5 1-(4-methylphenyl)-2-(4-trifluoromethylphenyl)acetylene 
• 64583-17-1 1-(4-fluorophenyl)-2-(4-methylphenyl)acetylene 
• 62856-42-2 1-(2-(4-bromophenyl)ethynyl)-4-methylbenzene 
• 22692-80-4 1-ethyl-4-(p-tolylethynyl)benzene 
• 65016-20-8 (4-methyl-phenyl)(3-methyl-phenyl)acetylene 
• 3287-02-3 4-(phenylethynyl)toluene 
• 2789-88-0 1,2-bis(4-methylphenyl)acetylene 

Relevant academic research and scientific papers

A general palladium-catalyzed cross-coupling of aryl fluorides and organotitanium (IV) reagents

Pd(OAc)2/1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxy-piperidine was demonstrated to effectively catalyze cross-coupling of aryl fluoride and aryl(alkyl) titanium reagent. Both electron-deficient and electron-rich aryl fluoride can react effectively with nucleophile and provide extensive functional groups tolerance. 2-Arylated product was realized by selective activation of the C–F bond. Graphic abstract: [Figure not available: see fulltext.].

Catalytic Enantioselective Arylation and Heteroarylation of Ketones with Organotitanium Reagents Generated In Situ

A practical and useful, catalytic enantioselective method has been developed for the synthesis of tertiary diaryl and aryl heteroaryl carbinols starting from commercially available aromatic ketones and aryl or heteroaryl bromides. In this method, organotitanium reagents are generated in situ from the bromides by lithiation with nBuLi followed by transmetallation of the resulting organolithiums with ClTi(OiPr)3. Treatment of the ketones with the titanium reagents in the presence of (R)-3-(3,5-bistrifluoromehthylphenyl)-1,1′-bi-2-naphthol (BTFP-BINOL) affords the corresponding tertiary alcohols in high enantioselectivities and yields. The reaction can also start with furan and 2-thienyllithium. The method is operationally simple and can be conducted on a 10-mmol scale without any difficulties.

Nickel-catalyzed substitution reactions of propargyl halides with organotitanium reagents

A simple and mild catalytic coupling reaction of propargyl halides with organotitanium reagents is reported. The reaction of propargyl bromide with organo-titanium reagents mediated by NiCl2(2 mol%) and PCy3(4 mol%) in CH2