1198463-95-4Relevant articles and documents
Four-component synthesis of β-enaminone and pyrazole through phosphine-free palladium-catalyzed cascade carbonylation
Shi, Lijun,Xue, Liqin,Lang, Rui,Xia, Chungu,Li, Fuwei
, p. 2560 - 2566 (2014)
The carbonylative domino synthesis of enaminones and pyrazoles has been performed with the N?N bidentate palladium catalyst to achieve excellent selectivity. These results have confirmed that the carbonylative Sonogashira coupling of iodobenzenes with ter
Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with α-Cl Ketones
Zhou, Jianhui,Li, Jian,Li, Yazhou,Wu, Chenglin,He, Guoxue,Yang, Qiaolan,Zhou, Yu,Liu, Hong
supporting information, p. 7645 - 7649 (2018/12/11)
In the present study, a novel synthetic strategy to directly produce versatile 3-acylindoles through Rh(III)-catalyzed C-H activation and annulation cascade of N-phenylamidines with α-Cl ketones was developed, in which α-Cl ketones serve as unusual one-carbon (sp3) synthons. This strategy features high regioselectivity, efficiency, wide substrate tolerance, and mild reaction conditions, which further underscore its synthetic utility in drug molecule synthesis.
Copper-catalyzed C-C bond formation through C-H functionalization: Synthesis of multisubstituted indoles from N-aryl enaminones
Bernini, Roberta,Fabrizi, Giancarlo,Sferrazza, Alessio,Cacchi, Sandro
supporting information; experimental part, p. 8078 - 8081 (2010/01/16)
A variety of functionalities, including the whole range of halogen substituents, are tolerated in the title reaction, an intramolecular approach for the construction of a multisubstituted indole skeleton from readily available enaminones (see scheme; phen=1,10-phenanthroline). The indole products are also prepared directly in high yield from α, β-ynones and primary amines.
