37003-83-1Relevant academic research and scientific papers
Four-component synthesis of β-enaminone and pyrazole through phosphine-free palladium-catalyzed cascade carbonylation
Shi, Lijun,Xue, Liqin,Lang, Rui,Xia, Chungu,Li, Fuwei
, p. 2560 - 2566 (2015/04/14)
The carbonylative domino synthesis of enaminones and pyrazoles has been performed with the N?N bidentate palladium catalyst to achieve excellent selectivity. These results have confirmed that the carbonylative Sonogashira coupling of iodobenzenes with ter
Anilines as substrates in consecutive four-component synthesis of novel 1-aryl-5-benzoyl-6-phenyl-3,4-dihydropyridin-2(1 H)-ones
Nordmann, Jan,Müller, Thomas J. J.
, p. 522 - 530 (2014/03/21)
The consecutive four-component synthesis of 5-acylpyridin-2(1H)-ones initiated by a copper-free alkynylation in a one-pot fashion has been expanded to include considerably less nucleophilic anilines as the amine component in the Michael addition step by altering the solvent system to 1,4-dioxane; 17 examples for the synthesis of 1-aryl-5-benzoyl-6-phenyl-3,4-dihydropyridin-2(1H) -ones were obtained in moderate to good yields.
Copper-catalyzed C-C bond formation through C-H functionalization: Synthesis of multisubstituted indoles from N-aryl enaminones
Bernini, Roberta,Fabrizi, Giancarlo,Sferrazza, Alessio,Cacchi, Sandro
supporting information; experimental part, p. 8078 - 8081 (2010/01/16)
A variety of functionalities, including the whole range of halogen substituents, are tolerated in the title reaction, an intramolecular approach for the construction of a multisubstituted indole skeleton from readily available enaminones (see scheme; phen=1,10-phenanthroline). The indole products are also prepared directly in high yield from α, β-ynones and primary amines.
