119860-22-9

Upstream product

• 7440-44-0 pyrographite 
• 119860-21-8 N¹-acetyl-N⁸-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-N⁴-(4-nitrobenzyloxycarbonyl)-1,4,8-octanetriamine 
• 119860-19-4 N⁸-benzyloxycarbonyl-N¹-tert-butoxycarbonyl-2,2-difluoro-3-hydroxy-N⁴-(4-nitrobenzyloxycarbonyl)-1,4,8-octanetriamine 
• 119860-18-3 8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(4-nitrobenzyloxycarbonylamino)octanamide 
• 119860-20-7 [8-Amino-7,7-difluoro-6-hydroxy-5-(4-nitro-benzyloxycarbonylamino)-octyl]-carbamic acid benzyl ester 
• 119860-17-2 8-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-4-(R,S)-(4-nitrobenzyloxycarbonylamino) octanoic acid ethyl ester 
• 138802-24-1 (R,S)-1-formyl-1-(4-nitrobenzyl)-5-benzylpentylene dicarbamate 

Downstream Products

• 129476-16-0 N-tert-butoxycarbonyl-D-phenylalanyl-N-<1-(3-acetylamino-2,2-difluoro-1-hydroxy-propyl)-5-benzyloxycarbonylaminopentyl>-L-prolinamide 
• 129476-12-6 N-tert-butoxycarbonyl-D-phenylalanyl-N-<1-(3-acetylamino-2,2-difluoro-1-oxo-propyl)-5-tert-butoxycarbonylaminopentyl>-L-prolinamide 

Relevant academic research and scientific papers

Difluoromethyleneketone retroamide, a versatile concept of inactivation of proteolytic enzymes

The synthesis of difluoromethyleneketone retroamides is described. Several examples of application to aspartyl or seryl proteases illustrate the versatility of this inactivation concept. Copyright

Novel peptidase inhibitors

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide bond of a partial retropeptide analog of the substrate has been replaced by a difluoromethylene moiety. These peptidase substrate analogs provide specific enzyme inhibitors for a variety of proteases, the inhibition of which exert valuable pharmacological activities and therefore have useful physiological consequences in a variety of disease states.

Novel peptidase inhibitors

This invention relates to activated electrophilic ketone retroamide analogs of certain peptidase substrates having the formula R1NHCHR2COCF2CHR3(NRbCOXRa)nQ These compounds are useful in inhibiting serine-, thiol-, carboxylic acid- and metallo- dependent