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1198615-70-1

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1198615-70-1 Usage

Description

(3-Ethoxycarbonylmethyl)phenylboronic Acid, Pinacol Ester is a chemical compound with the molecular formula C11H15BO4. It is a derivative of boronic acid and is characterized by its ability to form stable covalent bonds with diols, making it a versatile reagent in various chemical and biological applications.

Uses

Used in Pharmaceutical Industry:
(3-Ethoxycarbonylmethyl)phenylboronic Acid, Pinacol Ester is used as a reagent for the identification of a novel class of autotaxin inhibitors through cross-screening. Autotaxin is an enzyme involved in various biological processes, and its inhibition has potential therapeutic applications in treating diseases such as cancer and fibrosis. The compound's ability to form stable bonds with diols allows for the selective identification and characterization of autotaxin inhibitors, contributing to the development of new therapeutic strategies.

Check Digit Verification of cas no

The CAS Registry Mumber 1198615-70-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,8,6,1 and 5 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1198615-70:
(9*1)+(8*1)+(7*9)+(6*8)+(5*6)+(4*1)+(3*5)+(2*7)+(1*0)=191
191 % 10 = 1
So 1198615-70-1 is a valid CAS Registry Number.

1198615-70-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

1.2 Other means of identification

Product number -
Other names ethyl 2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1198615-70-1 SDS

1198615-70-1Relevant articles and documents

PRMT5 INHIBITORS AND USES THEREOF

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Paragraph 0382-0383, (2019/04/05)

Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF

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Paragraph 00324, (2014/07/08)

Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5- mediated disorders are also described.

Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis

Scott, Jill M.,Baccei, Christopher,Bain, Gretchen,Broadhead, Alex,Evans, Jilly F.,Fagan, Patrick,Hutchinson, John H.,King, Christopher,Lorrain, Daniel S.,Lee, Catherine,Prasit, Peppi,Prodanovich, Pat,Santini, Angelina,Santini, Brian A.

, p. 6608 - 6612 (2011/12/04)

Biphenylacetic acid (5) was identified through a library screen as an inhibitor of the prostaglandin D2 receptor DP2 (CRTH2). Optimization for potency and pharmacokinetic properties led to a series of selective CRTH2 antagonists. Compounds demonstrated potency in a human DP2 binding assay and a human whole blood eosinophil shape change assay, as well as good oral bioavailability in rat and dog, and efficacy in a mouse model of allergic rhinitis following oral dosing.

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