119866-78-3

Upstream product

• 110920-05-3 methyl ester of 2-(N-phenylimino)trifluoropropanoic acid 
• 2325-27-1 N-phenyltriphenyliminophosphorane 
• 622-37-7 Phenyl azide 
• 110920-05-3 2-(N-Phenylimino)trifluoropropanoic acid methyl ester 

Downstream Products

• 1429486-31-6 1-phenyl-5-trifluoromethyl-3-trimethylsilyl-1H-pyrazol-4-ol 
• 265119-91-3 1-phenyl-5-trifluoromethyl-1H-pyrazol-3(2H)-one 
• 1396123-90-2 1-phenyl-3-(n-butyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole 
• 1396123-89-9 1-phenyl-3-trimethylsilyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole 
• 1396123-95-7 1-phenyl-4-trimethylsilyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole 
• 1396123-91-3 1-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole 
• 1396123-88-8 1,3,4-triphenyl-5-(trifluoromethyl)-1H-pyrazole 
• 1396123-87-7 1,3-diphenyl-4-(n-butyl)-5-trifluoromethyl-1H-pyrazole 
• 1396123-94-6 1,4-diphenyl-3-(n-butyl)-5-trifluoromethyl-1H-pyrazole 
• 1429485-70-0 1-phenyl-3-(3-chloropropyl)-5-trifluoromethyl-1H-pyrazole 
• 1396123-86-6 3-(benzyloxymethyl)-1-phenyl-5-trifluoromethyl-1H-pyrazole 
• 1429485-66-4 1-phenyl-3-(cyclohex-1-enyl)-5-trifluoromethyl-1H-pyrazole 
• 1396123-85-5 1-phenyl-3-trimethylsilyl-5-trifluoromethyl-1H-pyrazole 
• 957188-42-0 1-phenyl-3-n-butyl-5-trifluoromethyl-1H-pyrazole 

Relevant academic research and scientific papers

Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions

We report the synthesis and some structural studies of 4-trifluoromethyl, 4-difluoromethyl-, and 4-monofluoromethylsydnones. All but the latter compounds are stable and represent effective precursors to a range of pyrazoles after cycloaddition reactions with alkynes. The cycloadditions are generally highly regioselective and provide 5-fluoromethylpyrazole products, although we have observed that Bn-substituted sydnones can provide an unexpected alkyne insertion mode that generates the 3-fluoromethyl isomer.

A general and regioselective synthesis of 5-trifluoromethyl-pyrazoles

Two synthetic approaches to 4-trifluoromethylsydnones, a novel class of these mesoionic reagents, are reported. These compounds undergo regioselective alkyne cycloaddition reactions, thereby providing a general approach to 5-trifluoromethylpyrazoles. This method has been employed in a short formal synthesis of the herbicide fluazolate.

FLUORINE-CONTAINING AMINO ACIDS. V. IMINES OF TRIFLUOROPYRUVIC ACID IN THE SYNTHESIS OF N-SUBSTITUTED TRIFLUOROALANINES

N-Substituted trifluoroalanine methyl esters were obtained by the reduction of the corresponding imines of trifluoropyruvic acid with zinc in acetic acid.The N-butyl- and N-(1-phenylethyl)imines undergo a -proton shift under the influence of bases with the formation of trifluoroalanine derivatives.It was found that the N-(1-phenylethyl)imine of tetrafluoropyruvic acid is formed directly from the corresponding amine and methyl trifluoropyruvate under conditions with azeotropic distillation of the water with toluene in the presence of acidic catalysis.