957188-42-0Relevant articles and documents
Novel 4,5-bis(trifluoromethyl)-1H-pyrazoles through a concise sequential iodination-trifluoromethylation reaction
Junges, Andrizia F.,Pittaluga, Everton P.,Zanatta, Nilo,Martins, Marcos A.P.,Bonacorso, Helio G.
, p. 1385 - 1388 (2019/04/30)
An efficient protocol for the assembly of a new series of 1,3-disubstituted 4,5-bis(trifluoromethyl)-1H-pyrazoles – through a concise sequential iodination-trifluoromethylation reaction at the C-4 position of an initial series of 1-aryl-3-(alkyl/aryl)-5-trifluoromethyl-1H-pyrazoles (electronically deactivated heterocycles), using NIS and MFSDA, at good conversion yields and in short reaction times – is reported.
Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions
Foster, Robert S.,Adams, Harry,Jakobi, Harald,Harrity, Joseph P. A.
, p. 4049 - 4064 (2013/06/05)
We report the synthesis and some structural studies of 4-trifluoromethyl, 4-difluoromethyl-, and 4-monofluoromethylsydnones. All but the latter compounds are stable and represent effective precursors to a range of pyrazoles after cycloaddition reactions with alkynes. The cycloadditions are generally highly regioselective and provide 5-fluoromethylpyrazole products, although we have observed that Bn-substituted sydnones can provide an unexpected alkyne insertion mode that generates the 3-fluoromethyl isomer.
Synergic effects of ionic liquid and microwave irradiation in promoting trifluoromethylpyrazole synthesis
Buriol, Lilian,Frizzo, Clarissa P.,Prola, Lizie D. T.,Moreira, Dayse N.,Marzari, Mara R. B.,Scapin, Elisandra,Zanatta, Nilo,Bonacorso, Helio G.,Martins, Marcos A. P.
experimental part, p. 1130 - 1135 (2012/06/18)
The synthesis of 5-trifluoromethyl-1-phenyl-1H-pyrazoles from the reactions of 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones [CF3C(O)CH=C(R 1)OR, where R = Me, Et; R1= H, Me, Bu, i-Bu, Ph, 4-MeC6H4, 4-FCsu
