1198769-40-2

Upstream product

• 1198769-39-9 5-iodo-4-phenyl-1-(3-(trifluoromethyl)benzyl)-1H-1,2,3-triazole 
• 620533-90-6 1‐(azidomethyl)‐3‐(trifluoromethyl)benzene 
• 932-88-7 1-iodo-2-phenylethyne 
• 536-74-3 phenylacetylene 
• 402-23-3 1-bromomethyl-3-trifluoromethylbenzene 
• 588-73-8 (Z)-β-bromostyrene 
• 637-44-5 phenylpropyolic acid 
• 705-29-3 3-Trifluoromethylbenzyl chloride 
• 588-72-7 [(E)-2-bromoethenyl]benzene 

Relevant academic research and scientific papers

Experimental evidence for the involvement of dinuclear alkynylcopper(I) complexes in alkyne-azide chemistry

Dinuclear alkynylcopper(I) ladderane complexes are prepared by a robust and simple protocol involving the reduction of Cu2(OH)3OAc or Cu-(OAc)2 by easily oxidised alcohols in the presence of terminal alkynes; they function

Multi-component reaction for the preparation of 1,5-disubstituted 1,2,3-triazoles by in-situ generation of azides and nickel-catalyzed azide-alkyne cycloaddition

An efficient one-pot procedure combining bromide conversion into azide followed by NiAAC for the preparation of 1,5-disubstituted 1,2,3-triazoles has been developed. This procedure prevents the use of isolated azides, which are insufficiently commercially

Water as a solvent for Ru-catalyzed click reaction: Highly efficient recyclable catalytic system for triazolocoumarins synthesis

A new family of Ru (III) complexes has been synthesized, characterized and their catalytic performance has been tested for alkyne–azide cycloaddition (AAC) in water under ultrasonic irradiation conditions. These complexes are found to be effective heterog

Method used for synthesizing 1, 4-substituted 1, 2, 3-triazole from terminal alkyne multiple components

The invention belongs to the technical field of nitrogen containing compound preparation, and discloses a method used for synthesizing 1, 4-substituted 1, 2, 3-triazole from terminal alkyne multiple components. The method comprises following steps: 1.2 eq

Preparation method for synthesizing 1,4-substituted 1,2,3-triazole from organic azide and terminal alkynes

The invention belongs to the technical field of nitrogen-containing compound preparation, discloses a preparation method for synthesizing 1,4-substituted 1,2,3-triazole from organic azide and terminalalkynes, provides a method which is used for preparing

Method for synthesizing 1,4-substituted 1,2,3-triazole by alkynoic acid multi-components

The invention belongs to the technical field of preparation of nitrogen-containing compounds, and discloses a method for synthesizing 1,4-substituted 1,2,3-triazole by alkynoic acid multi-components.The method comprises the following steps: adding 1.2 equivalents of a (pseudo) halide, 1.5 equivalents of an azide reagent, 1.0 equivalent of alkynoic acid, 0.1 equivalent of cuprous iodide, 0.2 equivalent of potassium carbonate or potassium hydroxide and a solvent polyethylene glycol 400 into a reaction bottle, and carrying out stirring for a reaction; after the reaction is determined to be finished by thin layer chromatography plate pointing, adding water, adding ethyl acetate for extraction, combining the ethyl acetate, drying the ethyl acetate layer by anhydrous sodium sulfate, and carrying out concentrating under reduced pressure to obtain a crude product; and performing column chromatography to obtain the corresponding 1,4-substituted 1,2,3-triazole. According to the invention, the target product 1,4-substituted 1,2,3-triazole is synthesized in one step; the toxicity of a used catalyst is low, reaction conditions are mild, operation is simple and convenient, the yield is high, cost is low, and the reaction process is green and environmentally friendly; and thus the method is suitable for industrial production.

Method for synthesizing P-1,4- substituted triazole 1, 2, 3- in alkynylic acid (by machine translation)

The method comprises the following steps: adding water to a reaction bottle; adding water to 1,4 - the 1, 2, 3 - reaction flask; adding water; extracting with ethyl acetate; extracting with 1.2 ethyl acetate; 1.0 adding ethyl acetate; 0.05 drying the ethy

Green synthesis of 1,2,3-triazoles via Cu2O NPs on hydrogen trititanate nanotubes promoted 1,3-dipolar cycloadditions

Cu2O nanoparticles supported on hydrogen trititanate nanotubes (Cu2O/HTNT) catalysts have been efficiently catalyzed the multicomponent synthesis of 1,2,3-triazoles in water at room temperature from different azide precursors, for example organic halides, sulfonates and anilines. The catalysts were synthesized by hydrothermal & wet-impregnation methods and was characterized by HR-TEM, EDS, XRD, XPS, N2-adsorption desorption and ICP-MS analysis. The catalyst could be recycled by centrifugation and reused up to seven cycles. The 1-benzyl-4-(4-chlorophenyl)-1H-1,2,3-triazole (25) structure was proven by single crystal X-ray diffraction studies.

Method for preparing 1, 4-substituted-1, 2, 3-triazole from (Z)-beta-alkenyl bromide multicomponents and use thereof

The invention relates to a method for preparing 1, 4-substituted-1, 2, 3-triazole from (Z)-beta-alkenyl bromide multicomponents and a use thereof and belongs to the technical field of preparation of 1, 4-substituted-1, 2, 3-triazole. The method comprises that a copper catalyst and a base are added into a halide, an azide reagent and (Z)-beta-alkenyl bromide as raw materials, the mixture is stirred in a solvent at a certain temperature and undergoes a reaction, and the reaction products are separated and purified so that 1, 4-substituted-1, 2, 3-triazole is obtained. The method has the advantages of easy availability of raw materials, low cost, mild reaction condition, simple operation, high yield, environmental friendliness in the reaction process and industrial production feasibility.

A New Simplified Protocol for Copper(I) Alkyne-Azide Cycloaddition Reactions Using Low Substoichiometric Amounts of Copper(II) Precatalysts in Methanol

Copper(II) carboxylates are reduced efficiently by methanol in the presence of alkynes and form yellow alkynylcopper(I) polymeric precatalysts that are involved with azides, in the absence of added ligands, in the catalytic cycles that result in the forma