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588-73-8

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588-73-8 Usage

General Description

[(Z)-2-Bromoethenyl]benzene, also known as phenyl vinyl bromide, is a chemical compound with the molecular formula C8H7Br. It is an organic compound consisting of a benzene ring with a vinyl bromide group attached to it. [(Z)-2-Bromoethenyl]benzene is commonly used in organic synthesis and as a precursor in the production of various organic compounds. The vinyl bromide group makes it a useful building block for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is important to handle this compound with care as it is a flammable liquid and can also be harmful if inhaled, ingested, or absorbed through the skin.

Check Digit Verification of cas no

The CAS Registry Mumber 588-73-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,8 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 588-73:
(5*5)+(4*8)+(3*8)+(2*7)+(1*3)=98
98 % 10 = 8
So 588-73-8 is a valid CAS Registry Number.

588-73-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name [(Z)-2-bromoethenyl]benzene

1.2 Other means of identification

Product number -
Other names Benzene, (2-bromoethenyl)-, (Z)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:588-73-8 SDS

588-73-8Relevant articles and documents

On the planarity of styrene and its derivatives: The molecular structures of styrene and (Z)-β-bromostyrene as determined by ab initio calculations and gas-phase electron diffraction

Cochran, John C.,Hagen, Kolbjorn,Paulen, Gunnar,Shen, Quang,Tom, Samson,Traetteberg, Marit,Wells, Christopher

, p. 313 - 326 (1997)

The molecular structures of styrene and (Z)-β-bromostyrene have been studied in the gas phase at nozzle temperatures of 303 and 338 K respectively. For both molecules the electron diffraction data were consistent with the results from ab initio calculatio

Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods

Makley, Leah N.,Johnson, Oleta T.,Ghanakota, Phani,Rauch, Jennifer N.,Osborn, Delaney,Wu, Taia S.,Cierpicki, Tomasz,Carlson, Heather A.,Gestwicki, Jason E.

, (2021/02/09)

Destabilizing mutations in small heat shock proteins (sHsps) are linked to multiple diseases; however, sHsps are conformationally dynamic, lack enzymatic function and have no endogenous chemical ligands. These factors render sHsps as classically “undruggable” targets and make it particularly challenging to identify molecules that might bind and stabilize them. To explore potential solutions, we designed a multi-pronged screening workflow involving a combination of computational and biophysical ligand-discovery platforms. Using the core domain of the sHsp family member Hsp27/HSPB1 (Hsp27c) as a target, we applied mixed solvent molecular dynamics (MixMD) to predict three possible binding sites, which we confirmed using NMR-based solvent mapping. Using this knowledge, we then used NMR spectroscopy to carry out a fragment-based drug discovery (FBDD) screen, ultimately identifying two fragments that bind to one of these sites. A medicinal chemistry effort improved the affinity of one fragment by ~50-fold (16 μM), while maintaining good ligand efficiency (~0.32 kcal/mol/non-hydrogen atom). Finally, we found that binding to this site partially restored the stability of disease-associated Hsp27 variants, in a redox-dependent manner. Together, these experiments suggest a new and unexpected binding site on Hsp27, which might be exploited to build chemical probes.

Visible light-mediated metal-free double bond deuteration of substituted phenylalkenes

Iakovenko, Roman,Hlavá?, Jan

, p. 440 - 446 (2021/01/28)

Various bromophenylalkenes were reductively photodebrominated by using 1,3-dimethyl-2-phenyl-1H-benzo-[d]imidazoline (DMBI) and 9,10-dicyanoanthracene. With deuterated DMBI analogs (the most effective was DMBI-d11), satisfactory to excellent isotopic yields were obtained. DMBI-d11 could also be regenerated from the reaction mixtures with a recovery rate of up to 50%. The combination of the photodebromination reaction with conventional methods for bromoalkene synthesis enables sequential monodeuteration of a double bond without the necessity of a metal catalyst. This journal is

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