119899-81-9

Upstream product

• 88759-56-2 (S)-bromo-3-hydroxybutyric acid methyl ester 
• 119673-72-2 (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 119673-71-1 Methyl 3S-((t-butyl)diphenylsilyloxy)-4-bromo butanoate 
• 119900-72-0 (S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 119899-86-4 (S)-4-(Methoxychlorophosphinyl)-3-[[(t-butyl)diphenylsilyl]oxy]-butanoic acid, methyl ester 
• 137586-70-0 (S)-4-({2-[6-tert-Butyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester 
• 129122-54-9 (S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester 
• 137604-56-9 (S)-4-{[6-Cyclopropyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-3-hydroxy-butyric acid methyl ester 
• 135427-19-9 (S)-4-<<2-<4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinyl>ethyl>methoxyphosphinyl>-3-hydroxybutanoic acid methyl ester 

Relevant academic research and scientific papers

Phosphorus-Containing Inhibitors of HMG-CoA Reductase. 2. Synthesis and Biological Activites of a Series of Substituted Pyrydynes Containing a Hydroxyphosphinyl Moiety

A series of 2,3,4,(5),6-substituted pyridines containing a hydroxyphosphinyl functionality have been prepared and were evaluated for their ability to inhibit the enzyme HMG-CoA reductase.Systematic substitution of both R1-R4 and X-Y