119904-34-6

Basic information

• Product Name: (R)-(-)-1-cyano-1-(4-methylphenyl)methyl acetate
• Synonyms: (R)-(-)-1-cyano-1-(4-methylphenyl)methyl acetate
• CAS NO: 119904-34-6
• Molecular Weight: 189.214
• Mol File: 119904-34-6.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: (R)-(-)-1-cyano-1-(4-methylphenyl)methyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-1-cyano-1-(4-methylphenyl)methyl acetate(119904-34-6)
• EPA Substance Registry System: (R)-(-)-1-cyano-1-(4-methylphenyl)methyl acetate(119904-34-6)

Safety Data

• Hazardous Substances Data: 119904-34-6(Hazardous Substances Data)

Upstream product

• 108-22-5 Isopropenyl acetate 
• 4815-10-5 2-hydroxy-2-(4-methylphenyl)acetonitrile 
• 108-24-7 acetic anhydride 
• 104-87-0 4-methyl-benzaldehyde 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 10017-04-6 2-hydroxy-2-p-tolylacetonitrile 
• 139224-72-9 (R)-2-(4-methylphenyl)-2-trimethylsilyloxyacetonitrile 
• 75599-81-4 α-acetoxy-2-(4-methylphenyl)acetonitrile 
• 75-36-5 acetyl chloride 
• 66985-49-7 2-(4-methylphenyl)-2-(trimethylsilyloxy)acetonitrile 
• 773837-37-9 sodium cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 151-50-8 potassium cyanide 

Relevant articles and documents

Homochiral BINAPDA-Zr-MOF for Heterogeneous Asymmetric Cyanosilylation of Aldehydes

A new homochiral BINAPDA-Zr-MOF was prepared by a new chiral organic linker of (R)-4,4′-(6,6′-dichloro-2,2′-diethoxyl-[1,1′-binaphthalene]-4,4′-diyl)dibenzoic acid (R-L) and ZrCl4 under solvothermal conditions. Its structure was determined by P

The first porphyrin-salen based chiral metal-organic framework for asymmetric cyanosilylation of aldehydes

The first porphyrin-salen based chiral metal-organic framework (ps-CMOF) constructed by judiciously incorporating metalloporphyrin and metallosalen struts into one MOF structure is reported, which can serve as an effective heterogeneous catalyst for the a

High-Throughput Preparation of Optically Active Cyanohydrins Mediated by Lipases

Cyanohydrins are versatile compounds with high applicability in organic synthesis; they are used as starting materials for the synthesis of other chemical targets with high industrial added value. Lipase-mediated kinetic resolution reactions are a promising route for the synthesis of optically active cyanohydrins. These reactions can be carried out through the acylation of cyanohydrins or the deacylation of cyanohydrin esters, with different biocatalysts and under different reaction conditions. Unfortunately, depending on the substrate structure, long reaction times can be required to achieve suitable enantiomeric excesses. In this context, we present a high-throughput protocol for the production of optically active cyanohydrins in continuous-flow mode. The products were obtained with moderate to good enantioselectivity (E values from 8 up to >200) and with productivity values from 2.4 to 8.7 times higher in continuous-flow mode than in batch mode. Moreover, the reaction times were reduced from hours in batch mode to minutes in continuous-flow mode.