1199557-03-3

Basic information

• Product Name: 2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione
• CAS NO: 1199557-03-3
• Molecular Weight: 601.612
• Mol File: 1199557-03-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione(1199557-03-3)
• EPA Substance Registry System: 2-(trans-1-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-3-hydroxy-3-methylcyclobutyl)-1H-isoindole-1,3(2H)-dione(1199557-03-3)

Safety Data

• Hazardous Substances Data: 1199557-03-3(Hazardous Substances Data)

Upstream product

• 103-80-0 phenylacetyl chloride 
• 1199556-88-1 2-[trans-1-(4-bromophenyl)-3-hydroxy-3-methylcyclobutyl]-1H-isoindole-1,3(2H)-dione 
• 1199556-78-9 6-chloro-3-phenyl-1,5-naphthyridin-2(1H)-one 
• 1199557-04-4 tert-butyl (6-chloro-2-formylpyridin-3-yl)carbamate 
• 1199556-86-9 2-[2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]-1H-isoindole-1,3(2H)-dione 
• 1199556-87-0 2-[1-(4-bromophenyl)-3-oxocyclobutyl]-1H-isoindole-1,3(2H)-dione 
• 1199556-85-8 2-(4-bromophenyl)-5,8-dioxaspiro[3.4]octan-2-amine 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 1199557-05-5 tert-butyl [2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]carbamate 
• 1199557-02-2 7-chloro-1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridine 
• 1199556-90-5 2-{trans-3-hydroxy-3-methyl-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl}-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 1199556-40-5 trans-3-amino-3-{4-[1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7-yl]phenyl}-1-methylcyclobutanol 

Relevant articles and documents

INHIBITORS OF AKT ACTIVITY

The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also pro