119984-88-2

Upstream product

• 14235-81-5 4-Ethynylaniline 
• 3034-86-4 4-ethynylbenzoic acid methyl ester 
• 619-44-3 methyl 4-iodobenzoate 
• 75867-41-3 4-trimethylsilanylethynyl-benzoic acid methyl ester 
• 225928-10-9 4-(bromoethynyl)benzoic acid methyl ester 

Downstream Products

• 728877-74-5 4-[4-(4-aminophenyl)buta-1,3-diynyl]-N-{(1S,2S)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}benzamide 
• 728878-27-1 4-[(4'-aminophenyl)buta-1,3-diyn-1-yl]benzoic acid 
• 1276668-07-5 methyl (2S,3S)-2-{4'-[(4-aminophenyl)buta-1',3'-diynyl]benzamido}-3-hydroxybutanoate 
• 1363373-75-4 (2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate 
• 1363368-18-6 4-[(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide 
• 1363368-13-1 4-((4-aminophenyl)buta-1,3-diyn-1-yl)-N-((1S,2R)-1-hydroxy-3-(hydroxyamino)-1-(4-hydroxyphenyl)-3-oxopropan-2-yl)benzamide 
• 1363368-12-0 4-((4-aminophenyl)buta-1,3-diyn-1-yl)-N-((2S,3R)-3-hydroxy-1-(hydroxyamino)-3-(4-hydroxyphenyl)-1-oxobutan-2-yl)benzamide 
• 1363368-11-9 4-((4-aminophenyl)buta-1,3-diyn-1-yl)-N-((2S,3S)-3-hydroxy-1-(hydroxyamino)-3-(4-hydroxyphenyl)-1-oxobutan-2-yl)benzamide 
• 1363368-10-8 (S)-4-((4-aminophenyl)buta-1,3-diynyl)-N-(1-hydroxy-3-isopropyl-2-oxopyrrolidin-3-yI)benzamide 
• 1363368-08-4 4-((4-aminophenyl)buta-1,3-diynyl)-N-(1-hydroxy-2-oxopyrrolidin-3-yl)benzamide 
• 1363376-43-5 4-(4-(4-aminophenyl)buta-1,3-diynyl)-N-((3R)-3-hydroxy-1-(hydroxyamino)-1-oxo-3-(1H-1,2,3-triazol-4-yI)butan-2-yI)benzamide 
• 1363374-89-3 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-2-(4-((4-aminophenyl)buta-1,3-diyn-1-yl)benzamido)-3-hydroxy-3-(1H-1,2,3-triazol-4-yl)butanoate 
• 1363374-34-8 C₂₃H₂₂N₂O₄ 
• 791586-58-8 (2S,3R)-2-{4'-[(4''-aminophenyl)buta-1',3'-diynyl]benzamido}-1,3-dihydroxy-butanamide 

Relevant academic research and scientific papers

BENZOYLGLYCINE DERIVATIVES AND METHODS OF MAKING AND USING SAME

Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R1,R2, R3, R4, R5, R6, R7, R11, R12, R13/su

HYDROXYPYRIDINONE AND HYDROXYPYRIMIDINONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS

The present teachings relate to hydroxypyridinone and hydroxypyrimidinone derivatives, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections.

A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058

The difluoromethyl-allo-threonyl hydroxamate-based compound LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) in Gram-negative bacteria. A scalable synthesis of this compound is described. The key step

ETHYNYLBENZENE DERIVATIVES

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

Compounds inhibiting LpxC in the lipid A biosynthetic pathway are promising leads for novel antibiotics against multidrug-resistant Gram-negative pathogens. We report the syntheses and structural and biochemical characterizations of LpxC inhibitors based on a diphenyl-diacetylene (1,4-diphenyl-1,3-butadiyne) threonyl-hydroxamate scaffold. These studies provide a molecular interpretation for the differential antibiotic activities of compounds with a substituted distal phenyl ring as well as the absolute stereochemical requirement at the C2, but not C3, position of the threonyl group.