1363368-18-6

Upstream product

• 3034-86-4 4-ethynylbenzoic acid methyl ester 
• 1363373-75-4 (2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate 
• 119984-88-2 methyl 4-[(4'-aminophenyl)buta-1,3-diyn-1-yl]benzoate 
• 225928-10-9 4-(bromoethynyl)benzoic acid methyl ester 

Relevant academic research and scientific papers

BENZOYLGLYCINE DERIVATIVES AND METHODS OF MAKING AND USING SAME

Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R1,R2, R3, R4, R5, R6, R7, R11, R12, R13/su

A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058

The difluoromethyl-allo-threonyl hydroxamate-based compound LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) in Gram-negative bacteria. A scalable synthesis of this compound is described. The key step

ETHYNYLBENZENE DERIVATIVES

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.