1363373-75-4Relevant academic research and scientific papers
A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058
Liang, Xiaofei,Gopalaswamy, Ramesh,Navas, Frank,Toone, Eric J.,Zhou, Pei
, p. 4393 - 4398 (2016)
The difluoromethyl-allo-threonyl hydroxamate-based compound LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) in Gram-negative bacteria. A scalable synthesis of this compound is described. The key step
BENZOYLGLYCINE DERIVATIVES AND METHODS OF MAKING AND USING SAME
-
, (2017/12/15)
Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R1,R2, R3, R4, R5, R6, R7, R11, R12, R13/su
ETHYNYLBENZENE DERIVATIVES
-
Page/Page column 73; 77, (2012/03/26)
Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.
